Featured Research

from universities, journals, and other organizations

Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?

Date:
August 27, 2009
Source:
World Journal of Gastroenterology
Summary:
A new study found that anti-glycan antibodies were associated with celiac disease. Celiac patients with multiple anti-glycan antibodies of high titers had more frequently malabsorption than other symptoms. Contrary, presence of the anti-microbial antibodies did not show familial aggregation or association with mutations in NOD2/CARD15. Presence of anti-glycan antibodies in celiac disease is supposed secondary to the impaired gut barrier leading to sustained exposure to the gut microflora constituents via translocation.

Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet.

Related Articles


The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure. The presence of anti-microbial antibodies in relation to clinical presentation of the disease and NOD2/CARD15 mutations was also not investigated.

A research article to be published on August 21, 2009 in the World Journal of Gastroenterology addresses this question. Hungarian researchers from the University of Debrecen in Debrecen and the Semmelweis University in Budapest have shown in a well-characterized CD cohort that the anti-glycan antibody positivity is a common feature of celiac disease at the time of diagnosis and is lost after long-term gluten-free diet. The positivity rate and titers at diagnosis are as high as observed in Crohn's disease. The presence of anti-glycan antibodies is associated with the presenting symptoms, especially with severe malabsorption but not with mutations in NOD2/CARD15. No higher prevalence of anti-microbial antibodies is observed in the unaffected, first-degree relatives of this patient cohort.

Although the new data presented in the article may add new pieces to the puzzle of the anti-microbial antibody formation, the authors believe that it also assist to re-evaluate recently proposed genetically drived mechanism. Serological response to various microbial antigens might be considered a universal marker of the enhanced translocation of the gut microflora through the impaired small bowel mucosa both in celiac and Crohn's disease patients.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Papp M, Foldi I, Altorjay I, Palyu E, Udvardy M, TumpekJ, Sipka S, Korponay-Szabo IR, Nemes E, Veres G, Dinya T, Tordai A, Andrikovics H, Norman GL, Lakatos PL. Antimicrobial antibodies in celiac disease: Trick or treat? World J Gastroenterol, 2009; 15(31): 3891-3900

Cite This Page:

World Journal of Gastroenterology. "Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?." ScienceDaily. ScienceDaily, 27 August 2009. <www.sciencedaily.com/releases/2009/08/090826105933.htm>.
World Journal of Gastroenterology. (2009, August 27). Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2009/08/090826105933.htm
World Journal of Gastroenterology. "Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?." ScienceDaily. www.sciencedaily.com/releases/2009/08/090826105933.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins