Featured Research

from universities, journals, and other organizations

Collagen-deficient Mice Show Signs Of Osteoarthritis

Date:
August 31, 2009
Source:
Wiley-Blackwell
Summary:
Researchers conducted a study of mice to determine the effect of Type IX collagen (Col9a1) deficiency on functional ability. The authors found that mice with the Col9a1 gene inactivated prematurely develop OA and DDD.

Osteoarthritis (OA) and degenerative disc disease (DDD) are common, chronic musculoskeletal disorders. Both diseases cause joint pain, loss of function, and decreased quality of life for the more than 27 million OA and 59 million DDD suffers in the US. According to a 2003 Medical Expenditure Panel Survey, arthritis such as OA costs the U.S. economy nearly $128 billion per year in medical care and indirect expenses including lost wages and productivity.

Researchers at Duke University Medical Center, under a grant from the National Institutes of Health (NIH), conducted a study of mice to determine the effect of Type IX collagen (Col9a1) deficiency on functional ability. The authors found that mice with the Col9a1 gene inactivated prematurely develop OA and DDD. Findings of this study appear in the September issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology, published by Wiley-Blackwell.

Duke University researchers led by Kyle Allen, Ph.D. compared the behavioral abilities of Col9a1 deficient mice to wild-type (WT) mice. Mice of advanced age (9-11 months) were selected because they represent an age at which there is histological evidence of OA and DDD. Functional tests of reflexes, posture, strength, coordination, balance, sensorimotor skills, and gait were conducted to measure physical capabilities that could be impaired due to OA or DDD. Symptomatic pain was assessed through mechanical and thermal withdrawal thresholds.

"We observed a pattern of behavioral changes in the collagen deficient mice that suggests a relationship to OA- and DDD-like degeneration," stated Dr. Allen. The data shows that mice deficient in Type IX collagen clearly displayed behavioral characteristics of pain and functional loss. These mice had delayed righting reflex (ability to regain footing from a back position), decreased sensorimotor skills, and altered gait compared with WT mice. Collagen deficient mice also had elevated levels of knee and intervertebral disc structural changes.

According to the study, collagen deficient mice chose movements that limited peak joint forces and behaviors that reduced pain sensations. "In future work, these measures may help track signs and symptoms as degeneration progresses," added Dr. Allen. "Further studies of the mouse model could provide useful data for evaluating the efficacy of therapeutic interventions for musculoskeletal disorders."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kyle D. Allen, Timothy M. Griffin, Ramona M.Rodriguiz, William C. Wetsel, Virginia B. Kraus, Janet L. Huebner, Lawrence M. Boyd, Lori A. Setton. Decreased Physical Function and Increased Pain Sensitivity in Mice Deficient for Type IX Collagen. Arthritis & Rheumatism, 2009; DOI: 10.1002/art.24783

Cite This Page:

Wiley-Blackwell. "Collagen-deficient Mice Show Signs Of Osteoarthritis." ScienceDaily. ScienceDaily, 31 August 2009. <www.sciencedaily.com/releases/2009/08/090827072437.htm>.
Wiley-Blackwell. (2009, August 31). Collagen-deficient Mice Show Signs Of Osteoarthritis. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2009/08/090827072437.htm
Wiley-Blackwell. "Collagen-deficient Mice Show Signs Of Osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2009/08/090827072437.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins