Featured Research

from universities, journals, and other organizations

A New Molecule To Combat Diabetes And Obesity

Date:
September 3, 2009
Source:
Ecole Polytechnique Fédérale de Lausanne
Summary:
Type 2 diabetes, the most common form of diabetes, is increasing at an alarming state with more than 180 million people affected worldwide. With the rising incidence of obesity, a major risk factor for the onset of type 2 diabetes, this metabolic disorder represents a major health concern. Scientists in France now show that there may exist new ways to fight these disorders.

Type 2 diabetes, the most common form of diabetes, is increasing at an alarming state with more than 180 million people affected worldwide. With the rising incidence of obesity, a major risk factor for the onset of type 2 diabetes, this metabolic disorder represents a major health concern. A group from the Ecole Polytechnique Fédérale de Lausanne, now shows that there may exist new ways to fight these disorders.

Related Articles


The study, published in the current issue of the scientific journal Cell Metabolism (September 2, 2009), demonstrates that activation of the protein -TGR5- can treat type 2 diabetes and reduce weight gain. In collaboration with Prof. Roberto Pellicciari and his team at the University of Perugia (Italy), and Intercept Pharmaceuticals (New York, USA; Perugia, Italy), the group at the EPFL, led by Dr Kristina Schoonjans and Prof. Johan Auwerx, have characterized the metabolic properties of a selective TGR5 activator (INT-777), a drug with a promising future for the treatment of diabetes and obesity.

Earlier work from the same group showed that bile acids (endogenous molecules involved in digestion), via the activation of TGR5 in muscle and brown adipose tissue, are able to boost energy expenditure and to prevent or reverse diet-induced obesity in mice.

In the present study, the group of Dr Kristina Schoonjans and Prof. Johan Auwerx went further in studying the role of TGR5 in the gut where TGR5 is expressed in cells specialized in the production of gut-derived hormones. The authors found that in these so-called enteroendocrine cells TGR5 controls the secretion of the hormone Glucagon-Like Peptide 1 (GLP-1), which plays a critical role in the control of pancreatic function and the regulation of blood sugar levels.

In addition to this discovery and in collaboration with Prof. Roberto Pellicciari, who designed the novel potent and selective TGR5 activator, INT-777, under a longstanding collaboration with Intercept Pharmaceuticals, the group at the EPFL has shown that under laboratory conditions this compound can effectively treat diabetes and reduce fat mass. The authors have furthermore demonstrated that these effects were related to the increase in both GLP-1 secretion and energy expenditure.

This work is of great interest since it could herald a new approach in the treatment of type 2 diabetes and obesity.

"Recently, two classes of drugs exploiting the properties of the hormone GLP-1 have been marketed for the treatment of type 2 diabetes. The first strategy aims to increase the blood levels of GLP-1 by limiting its degradation in the body. The second is to mimic the effects of GLP-1 using drugs activating the GLP-1 receptor (GLP-1R)," explains Charles Thomas, first author of the study.

In this study, the authors propose a third therapeutic option based on increasing GLP-1 secretion via administration of TGR5 agonist therapy. The results obtained by the authors are even more spectacular since in addition to stimulating the secretion of GLP-1, INT-777 activation of TGR5 in other tissues leads to an increase in energy expenditure responsible for a reduction in fat mass and obesity.


Story Source:

The above story is based on materials provided by Ecole Polytechnique Fédérale de Lausanne. Note: Materials may be edited for content and length.


Cite This Page:

Ecole Polytechnique Fédérale de Lausanne. "A New Molecule To Combat Diabetes And Obesity." ScienceDaily. ScienceDaily, 3 September 2009. <www.sciencedaily.com/releases/2009/09/090901122631.htm>.
Ecole Polytechnique Fédérale de Lausanne. (2009, September 3). A New Molecule To Combat Diabetes And Obesity. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2009/09/090901122631.htm
Ecole Polytechnique Fédérale de Lausanne. "A New Molecule To Combat Diabetes And Obesity." ScienceDaily. www.sciencedaily.com/releases/2009/09/090901122631.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

85 Killed in Niger by Meningitis Since Start of Year

85 Killed in Niger by Meningitis Since Start of Year

AFP (Apr. 24, 2015) — A meningitis outbreak in Niger has killed 85 people since the start of the year prompting authorities to close schools in the capital Niamey until Monday. Video provided by AFP
Powered by NewsLook.com
C-Section Births a Trend in Brazil

C-Section Births a Trend in Brazil

AFP (Apr. 24, 2015) — More than half of Brazil&apos;s babies are born via cesarean section, as mothers and doctors opt for a faster and less painful experience despite the health risks. Duration: 02:02 Video provided by AFP
Powered by NewsLook.com
Anti-Malaria Jab Hope

Anti-Malaria Jab Hope

Reuters - News Video Online (Apr. 24, 2015) — The world&apos;s first anti-malaria vaccine could get the go-ahead for use in Africa from October if approved by international regulators. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) — Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins