Featured Research

from universities, journals, and other organizations

Mechanism That Constructs Key Brain Structure Discovered

Date:
September 17, 2009
Source:
Yale University
Summary:
Researchers have found a molecular mechanism that allows the proper mixing of neurons during the formation of columns essential for the operation of the cerebral cortex.

Neurons in green are over expressing a key gene that abnormally segregates them from other neurons (red and blue) within a developing column in the cerebral cortex.
Credit: Image courtesy of Yale University

Yale University researchers have found a molecular mechanism that allows the proper mixing of neurons during the formation of columns essential for the operation of the cerebral cortex, they report in the Sept. 16 online issue of the journal Nature.

Scientists have known for years that information processing in the cerebral cortex depends upon groupings of neurons that assemble in the shape of vertical columns. If the number and mix of neurons in the column are wrong, severe cognitive problems can result. For instance, malformations of these columns have been implicated in some forms of autism and mental retardation. Scientists, however, have not been able to find the molecular mechanism responsible for this intermixing.

In the Nature paper, a team led by Pasko Rakic, professor and chairman of the Department of Neurobiology and head of the Kavli Institute for Neuroscience, describes one of the molecular mechanisms essential to the organizations of these key structures.

Using the most advanced molecular technology, the Yale team showed that during neuronal migration, the intermixing of neurons within column depends on the expression levels of two genes - A-type Eph receptor and ephrin-As, a ligand, or molecule that binds to the receptor. Neuronal cells failed to move laterally into proper columns in mice lacking the ligands or receptors, the team reported.

Masaaki Torii, the first author of the paper, said he was surprised to find that the tiny lateral shift of migrating neurons controlled by these molecules plays such a pivotal role in the normal cortical development.

"This so far unrecognized mechanism for lateral neuronal dispersion seems to be essential for the proper intermixing of neuronal types in the cortical columns, which, when disrupted, might contribute to neuropsychiatric disorders " said Rakic.

Kazue Hashimoto-Torii of Yale as also an author of the paper.

The research was funded by the National Institutes of Health and the Kavli Institute for Neuroscience at Yale.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Mechanism That Constructs Key Brain Structure Discovered." ScienceDaily. ScienceDaily, 17 September 2009. <www.sciencedaily.com/releases/2009/09/090916133519.htm>.
Yale University. (2009, September 17). Mechanism That Constructs Key Brain Structure Discovered. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/09/090916133519.htm
Yale University. "Mechanism That Constructs Key Brain Structure Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/09/090916133519.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Hundreds in Virginia Turn out for a Free Clinic to Manage Health

Hundreds in Virginia Turn out for a Free Clinic to Manage Health

AFP (July 24, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th - prompting hundreds in Virginia to turn out for a free clinic run by “Remote Area Medical”. Duration 02:40 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins