Featured Research

from universities, journals, and other organizations

Protein Helps Distinguish Chromosome Ends From DNA Breaks

Date:
September 20, 2009
Source:
Stowers Institute for Medical Research
Summary:
Researchers have demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. The work follows the team's 2007 in vitro demonstration of the role of the hRAP1 protein in preventing chromosome ends from being fused to new DNA breaks.

The Stowers Institute's Baumann Lab has demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. The work, published in The EMBO Journal, a publication of the European Molecular Biology Organization, follows the team's 2007 in vitro demonstration of the role of the hRAP1 protein in preventing chromosome ends from being fused to new DNA breaks.

Related Articles


Chromosomes are linear. Their ends (called telomeres) should look like DNA breaks to the proteins that repair them. But somehow, cells are able to distinguish chromosome ends from DNA breaks. In this work, the team demonstrated that the human RAP1 protein plays a key role in preventing chromosome ends from being fused to new DNA breaks. Chromosome end fusions result in genomic instability, which can cause cancer. These findings suggest that RAP1 plays a critical role in cancer prevention in humans.

"Protecting naturally occurring chromosome ends from erosion and fusions may increase longevity and reduce cancer risk," said Jay Sarthy, formerly a graduate student in the Baumann Lab and lead author on the paper. "A protein that protects chromosome ends may provide an attractive target for drugs that can help to stave off aging and cancer."

"Our finding has paved the way to investigate the mechanism by which hRAP1 protects chromosome ends from undergoing fusions," said Peter Baumann, Ph.D., Associate Investigator and senior author on the publication. "This research contributes to our understanding of chromosome stability and, thereby, tumor suppression and cancer. If partial loss of hRAP1 function causes chromosomal instability, as suggested by our current work, then mutations in RAP1 may be linked to a predisposition for cancer."

Identifying hRAP1 as a critical protector of chromosome ends was an important step in understanding how telomeres are protected from DNA repair. The Baumann Lab will move forward in their efforts to understand what hRAP1 does to protect telomeres from repair — the proteins with which it interacts, and how it inactivates DNA repair specifically at chromosome ends.

Additional contributing authors from the Stowers Institute include Nancy Bae, Ph.D., formerly a Postdoctoral Research Associate; and Jonathan Scrafford, formerly a Summer Scholar.

Dr. Baumann is a Howard Hughes Medical Institute Early Career Scientist. He is also an Associate Professor in the Department of Molecular and Integrative Physiology at The University of Kansas School of Medicine.


Story Source:

The above story is based on materials provided by Stowers Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Stowers Institute for Medical Research. "Protein Helps Distinguish Chromosome Ends From DNA Breaks." ScienceDaily. ScienceDaily, 20 September 2009. <www.sciencedaily.com/releases/2009/09/090917144129.htm>.
Stowers Institute for Medical Research. (2009, September 20). Protein Helps Distinguish Chromosome Ends From DNA Breaks. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2009/09/090917144129.htm
Stowers Institute for Medical Research. "Protein Helps Distinguish Chromosome Ends From DNA Breaks." ScienceDaily. www.sciencedaily.com/releases/2009/09/090917144129.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins