Featured Research

from universities, journals, and other organizations

Protein Helps Distinguish Chromosome Ends From DNA Breaks

Date:
September 20, 2009
Source:
Stowers Institute for Medical Research
Summary:
Researchers have demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. The work follows the team's 2007 in vitro demonstration of the role of the hRAP1 protein in preventing chromosome ends from being fused to new DNA breaks.

The Stowers Institute's Baumann Lab has demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. The work, published in The EMBO Journal, a publication of the European Molecular Biology Organization, follows the team's 2007 in vitro demonstration of the role of the hRAP1 protein in preventing chromosome ends from being fused to new DNA breaks.

Chromosomes are linear. Their ends (called telomeres) should look like DNA breaks to the proteins that repair them. But somehow, cells are able to distinguish chromosome ends from DNA breaks. In this work, the team demonstrated that the human RAP1 protein plays a key role in preventing chromosome ends from being fused to new DNA breaks. Chromosome end fusions result in genomic instability, which can cause cancer. These findings suggest that RAP1 plays a critical role in cancer prevention in humans.

"Protecting naturally occurring chromosome ends from erosion and fusions may increase longevity and reduce cancer risk," said Jay Sarthy, formerly a graduate student in the Baumann Lab and lead author on the paper. "A protein that protects chromosome ends may provide an attractive target for drugs that can help to stave off aging and cancer."

"Our finding has paved the way to investigate the mechanism by which hRAP1 protects chromosome ends from undergoing fusions," said Peter Baumann, Ph.D., Associate Investigator and senior author on the publication. "This research contributes to our understanding of chromosome stability and, thereby, tumor suppression and cancer. If partial loss of hRAP1 function causes chromosomal instability, as suggested by our current work, then mutations in RAP1 may be linked to a predisposition for cancer."

Identifying hRAP1 as a critical protector of chromosome ends was an important step in understanding how telomeres are protected from DNA repair. The Baumann Lab will move forward in their efforts to understand what hRAP1 does to protect telomeres from repair — the proteins with which it interacts, and how it inactivates DNA repair specifically at chromosome ends.

Additional contributing authors from the Stowers Institute include Nancy Bae, Ph.D., formerly a Postdoctoral Research Associate; and Jonathan Scrafford, formerly a Summer Scholar.

Dr. Baumann is a Howard Hughes Medical Institute Early Career Scientist. He is also an Associate Professor in the Department of Molecular and Integrative Physiology at The University of Kansas School of Medicine.


Story Source:

The above story is based on materials provided by Stowers Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Stowers Institute for Medical Research. "Protein Helps Distinguish Chromosome Ends From DNA Breaks." ScienceDaily. ScienceDaily, 20 September 2009. <www.sciencedaily.com/releases/2009/09/090917144129.htm>.
Stowers Institute for Medical Research. (2009, September 20). Protein Helps Distinguish Chromosome Ends From DNA Breaks. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2009/09/090917144129.htm
Stowers Institute for Medical Research. "Protein Helps Distinguish Chromosome Ends From DNA Breaks." ScienceDaily. www.sciencedaily.com/releases/2009/09/090917144129.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Beijing Marathon Runners Brave Hazardous Air Pollution

Beijing Marathon Runners Brave Hazardous Air Pollution

AFP (Oct. 19, 2014) Tens of thousands of runners battled thick smog at the Beijing Marathon on Sunday, with some donning masks as the levels of PM2.5 small pollutant particles soared to 16 times the maximum recommended level. Duration: 00:54 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins