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Stem Cells Offer New Hope For Kidney Disease Patients

Date:
October 23, 2009
Source:
American Society of Nephrology
Summary:
Several cell-based therapy approaches could provide new treatments for patients with Alport syndrome, according to a new study.

This is Valerie LeBleu, Ph.D., and Raghu Kalluri, M.D., Ph.D., of the American Society of Nephrology.
Credit: Image courtesy of American Society of Nephrology

Several cell-based therapy approaches could provide new treatments for patients with Alport syndrome, reports an upcoming paper in the Journal of the American Society of Nephrology (JASN).

"Our study opens up many considerations of how new therapies related to the use of stem cells can be devised for our kidney patients with chronic disease," comments Raghu Kalluri, MD, PhD (Harvard Medical School, Boston, MA).

Led by Valerie LeBleu, PhD (also of Harvard Medical School), the researchers tested various types of cell-based therapy in mice with a gene defect similar to that causing Alport syndrome, a genetic kidney disease. Most often occurring in boys, Alport syndrome causes progressive kidney disease leading to kidney failure at a young age. Patients may develop hearing loss and eye disease as well. Although treatment can slow the progression of kidney disease, there is currently no cure for Alport syndrome.

The experiments provide evidence that stem cell treatments could repair the kidney defects associated with Alport syndrome. "We found that stem cells derived from adult bone marrow are equally useful as embryonic stem cells," says Kalluri. "This will make it easier to translate these scientific discoveries to a treatment protocol for patients with Alport syndrome."

Transplantation of bone marrow from unaffected animals significantly improved kidney function in mice in the late stages of disease. Importantly, the results suggested that the beneficial effects of bone marrow transplantation may be achieved without the need for radiation.

Simple blood transfusion from healthy mice also achieved dramatic improvements in kidney function and survival in the mice with end-stage kidney disease. "Bone marrow transplant and blood transfusion protocols have already been approved for previous clinical use in patients with end-stage kidney disease and Alport syndrome," says Kalluri. "Therefore, clinical application of this procedure is quite feasible and may help our patients immediately." Although the results in mice are promising, real effectiveness can only be tested in human clinical trials. Kalluri adds, "Our study is an important step towards that goal."

The authors received past and present funding from the Emerald Foundation, New York, National Institutes of Health, and the Department of Medicine at the Beth Israel Deaconess Medical Center.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Nephrology. "Stem Cells Offer New Hope For Kidney Disease Patients." ScienceDaily. ScienceDaily, 23 October 2009. <www.sciencedaily.com/releases/2009/10/091015171451.htm>.
American Society of Nephrology. (2009, October 23). Stem Cells Offer New Hope For Kidney Disease Patients. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2009/10/091015171451.htm
American Society of Nephrology. "Stem Cells Offer New Hope For Kidney Disease Patients." ScienceDaily. www.sciencedaily.com/releases/2009/10/091015171451.htm (accessed April 24, 2014).

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