Featured Research

from universities, journals, and other organizations

What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?

Date:
October 19, 2009
Source:
World Journal of Gastroenterology
Summary:
Focal nodular hyperplasia (FNH) is considered a hyperplastic lesion found in an otherwise normal liver, its clonality status has not been elucidated and the development of hepatocyte nodules within the involved parenchyma needs to be explained. A research group from China demonstrates that classical FNH is polyclonal in cell composition. However, the formation of multiple nodules of altered hepatocytes (NAH), showing monoclonality and genetic alterations, was found within all the FNH lesions.

Focal nodular hyperplasia (FNH) is a lesion found in an otherwise normal liver, and is considered to be parenchyma overgrowth responsive to increased blood flow secondary to vascular malformations. While its clinical outcomes are believed to be different from hepatocellular adenoma and carcinoma, its pathogenesis is largely unclear and its distinction from hepatocellular adenoma is sometimes difficult.

A research article to be published on October 7, 2009 in the World Journal of Gastroenterology addresses this question. The authors examined 12 FNH lesions via histological approaches, X-chromosome inactivation and allelotyping assays, using 12 hepatocellular adenomas and 22 hepatocellular carcinomas as references. Nodules of different types were isolated from FNH by microdissection and tested for clonality and genetic alterations.

Nodules of altered hepatocytes (NAH), the putative precursors of both hepatocellular adenoma and carcinoma, were found in all the FNH lesions. Polyclonality was revealed in all of the 10 FNH lesions, and loss of heterozygosity (LOH) was not detected in any of 6 FNH lesions examined, the results demonstrated their polyclonal nature and showed differences compared to hepatocellular neoplasms. In contrast, monoclonality was revealed in 21 (40%) of the 52 microdissected NAH. LOH was found in NAH, being highly frequent at 6 loci on 8p, 11p, 13q and 17p.

The results of clonality analyses provide an approach for the differential diagnosis of FNH from hepatocellular adenoma and well-differentiated carcinoma. In addition, elucidation of the pathogenesis the NAH, representing hepatocytic microadenoma, may lead to further understanding of early human hepatocarcinogenesis.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cai YR, Gong L, Teng XY, Zhang HT, Wang CF, Wei GL, Guo L, Ding F, Liu ZH, Pan QJ, Su Q. Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma. World Journal of Gastroenterology, 2009; 15 (37): 4695 DOI: 10.3748/wjg.15.4695

Cite This Page:

World Journal of Gastroenterology. "What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?." ScienceDaily. ScienceDaily, 19 October 2009. <www.sciencedaily.com/releases/2009/10/091019123116.htm>.
World Journal of Gastroenterology. (2009, October 19). What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/10/091019123116.htm
World Journal of Gastroenterology. "What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?." ScienceDaily. www.sciencedaily.com/releases/2009/10/091019123116.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins