Featured Research

from universities, journals, and other organizations

What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?

Date:
October 19, 2009
Source:
World Journal of Gastroenterology
Summary:
Focal nodular hyperplasia (FNH) is considered a hyperplastic lesion found in an otherwise normal liver, its clonality status has not been elucidated and the development of hepatocyte nodules within the involved parenchyma needs to be explained. A research group from China demonstrates that classical FNH is polyclonal in cell composition. However, the formation of multiple nodules of altered hepatocytes (NAH), showing monoclonality and genetic alterations, was found within all the FNH lesions.

Focal nodular hyperplasia (FNH) is a lesion found in an otherwise normal liver, and is considered to be parenchyma overgrowth responsive to increased blood flow secondary to vascular malformations. While its clinical outcomes are believed to be different from hepatocellular adenoma and carcinoma, its pathogenesis is largely unclear and its distinction from hepatocellular adenoma is sometimes difficult.

A research article to be published on October 7, 2009 in the World Journal of Gastroenterology addresses this question. The authors examined 12 FNH lesions via histological approaches, X-chromosome inactivation and allelotyping assays, using 12 hepatocellular adenomas and 22 hepatocellular carcinomas as references. Nodules of different types were isolated from FNH by microdissection and tested for clonality and genetic alterations.

Nodules of altered hepatocytes (NAH), the putative precursors of both hepatocellular adenoma and carcinoma, were found in all the FNH lesions. Polyclonality was revealed in all of the 10 FNH lesions, and loss of heterozygosity (LOH) was not detected in any of 6 FNH lesions examined, the results demonstrated their polyclonal nature and showed differences compared to hepatocellular neoplasms. In contrast, monoclonality was revealed in 21 (40%) of the 52 microdissected NAH. LOH was found in NAH, being highly frequent at 6 loci on 8p, 11p, 13q and 17p.

The results of clonality analyses provide an approach for the differential diagnosis of FNH from hepatocellular adenoma and well-differentiated carcinoma. In addition, elucidation of the pathogenesis the NAH, representing hepatocytic microadenoma, may lead to further understanding of early human hepatocarcinogenesis.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cai YR, Gong L, Teng XY, Zhang HT, Wang CF, Wei GL, Guo L, Ding F, Liu ZH, Pan QJ, Su Q. Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma. World Journal of Gastroenterology, 2009; 15 (37): 4695 DOI: 10.3748/wjg.15.4695

Cite This Page:

World Journal of Gastroenterology. "What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?." ScienceDaily. ScienceDaily, 19 October 2009. <www.sciencedaily.com/releases/2009/10/091019123116.htm>.
World Journal of Gastroenterology. (2009, October 19). What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/10/091019123116.htm
World Journal of Gastroenterology. "What's The Clonality Status And Allelotype Of Focal Nodular Hyperplasia?." ScienceDaily. www.sciencedaily.com/releases/2009/10/091019123116.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins