Featured Research

from universities, journals, and other organizations

Sex-based Prenatal Brain Differences Found

Date:
October 26, 2009
Source:
Uppsala University
Summary:
Prenatal sex-based biological differences extend to genetic expression in cerebral cortices. The differences in question are probably associated with later divergences in how our brains develop, according to a new study by researchers in Sweden.

Prenatal sex-based biological differences extend to genetic expression in cerebral cortices. The differences in question are probably associated with later divergences in how our brains develop. This is shown by a new study by Uppsala University researchers Elena Jazin and Björn Reinius, which has been published in the latest issue of the journal Molecular Psychiatry.

Professor Elena Jazin and doctoral student Björn Reinius at the Department of Physiology and Developmental Biology previously demonstrated that genetic expression in the cerebral cortices of human beings and other primates exhibits certain sex-based differences. It is presumed that these differences are very old and have survived the evolutionary process. The purpose of the new study was to determine whether they appear during the process of brain development or first upon the conclusion of that process. Identifying the initial genetic mechanisms that prompt the brain to develop in a female or male direction is a long-range research objective.

The Uppsala University researchers analysed data, on the basis of sex, from another extensive study of the prenatal human brain.

"The results show that many of the genes situated on the Y chromosome are expressed in various parts of the brain prior to birth and probably provide a developmental basis for the sex-based differences exhibited by adult brains," according to Elena Jazin.

More than a third of Y-chromosomal genes appear to be involved in sex-based human brain differentiation. Some of the genetic activity in question is evident in the adult brain, while other of it only appears at earlier stages of brain development. It is yet unknown whether the differences in genetic expression among female and male brains have any functional significance.

"The findings are consistent with other factors, such as environment, also playing a role in how we develop," emphasizes Elena Jazin.

Knowledge of the development of sex-based brain differences is of potential significance for the treatment of brain disturbances and diseases. A large number of psychiatric illnesses, including depression and autism, affect men and women differentially.

"Taking account of sex-based differences is crucial to the study of normal and abnormal brain activity," according to Elena Jazin.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Cite This Page:

Uppsala University. "Sex-based Prenatal Brain Differences Found." ScienceDaily. ScienceDaily, 26 October 2009. <www.sciencedaily.com/releases/2009/10/091023163350.htm>.
Uppsala University. (2009, October 26). Sex-based Prenatal Brain Differences Found. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/10/091023163350.htm
Uppsala University. "Sex-based Prenatal Brain Differences Found." ScienceDaily. www.sciencedaily.com/releases/2009/10/091023163350.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins