Featured Research

from universities, journals, and other organizations

Study Finds Best Use Of Insulin As Diabetes Progresses

Date:
October 26, 2009
Source:
University of Oxford
Summary:
A large-scale trial in diabetes patients has provided new evidence on how best to add insulin to standard drugs to control blood sugar levels as type 2 diabetes progresses.

A large-scale trial in diabetes patients has provided new evidence on how best to add insulin to standard drugs to control blood sugar levels as type 2 diabetes progresses.

The University of Oxford research was published in the New England Journal of Medicine to coincide with presentation of the final trial results at the World Diabetes Congress in Montreal, Canada.

Patients who added insulin, either through once-a-day (basal) insulin injections or three injections at mealtimes, to their oral anti-diabetes drugs showed better control of their blood sugar levels than those adding twice daily insulin injections.

Those starting with a single insulin injection each day also had fewer hypoglycaemic episodes (when blood sugar levels are too low) and gained less weight.

'Type 2 diabetes is a progressive condition with the majority of patients eventually requiring insulin therapy,' says Professor Rury Holman, principal investigator of the study and director of the Diabetes Trials Unit at Oxford University. 'This large-scale study strengthens guidelines recommending adding a basal insulin to oral agents when glycaemic targets are not met.'

Improved control of blood sugar levels is known to reduce the risk of complications in type 2 diabetes, such as kidney failure and loss of vision from eye disease. As type 2 diabetes progresses, the standard oral therapy will typically need to be escalated repeatedly over time.

Eventually, the majority of patients will require insulin but there remains uncertainty as to which regimen of insulin injections should be used when oral drugs become insufficient. There is no clear consensus about whether to start with insulin therapy three times a day with meals, injections twice a day, or a long-acting once-a-day insulin injection.

The researchers set out to find which pattern of treatment resulted in the best control of blood sugar levels. Their three-year, randomised controlled trial compared different insulin regimens in 708 patients with type 2 diabetes whose current doses of anti-diabetic drugs were not proving sufficient.

During the first year, the patients were randomised to one of the three insulin courses. During the second and third years, those who were still not achieving their glucose targets were moved to more complex insulin regimens.

Dr Jonathan Levy, lead clinician at the Oxford Centre for Diabetes, Endocrinology and Metabolism and co-principal investigator said: 'Starting with a basal insulin and adding a mealtime insulin if required provided the best combination of effectiveness, safety and treatment satisfaction'.

'These results will help patients and healthcare professionals in routine clinical practice to decide which treatment is most suitable for the individual,' added Dr Andrew Farmer, co-principal investigator at the Department of Primary Health Care.

Novo Nordisk and Diabetes UK provided funding for the study.


Story Source:

The above story is based on materials provided by University of Oxford. Note: Materials may be edited for content and length.


Cite This Page:

University of Oxford. "Study Finds Best Use Of Insulin As Diabetes Progresses." ScienceDaily. ScienceDaily, 26 October 2009. <www.sciencedaily.com/releases/2009/10/091025205419.htm>.
University of Oxford. (2009, October 26). Study Finds Best Use Of Insulin As Diabetes Progresses. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2009/10/091025205419.htm
University of Oxford. "Study Finds Best Use Of Insulin As Diabetes Progresses." ScienceDaily. www.sciencedaily.com/releases/2009/10/091025205419.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins