Featured Research

from universities, journals, and other organizations

Is Short-term Celecoxib Intervention A Effective Method For Preventing Gastric Carcinogenesis?

Date:
October 28, 2009
Source:
World Journal of Gastroenterology
Summary:
Helicobacter pylori has been accepted as an important pathogen inducing gastric cancer. A research group from Taiwan investigated optimal intervention point of Celecoxib, to inhibit H. pylori-associated gastric carcinogenesis in Mongolian gerbils. They found that short-term use resulted in less severe inflammation and inhibited the invasion degree of gastric cancer. Therefore, Celecoxib could be used in the later stages of H. pylori infection to achieve safe and effective chemoprevention of gastric adenocarcinoma.

Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer. Cyclooxgenase-2 (COX-2) is a prostaglandin-synthesizing enzyme. Elevated expression of COX-2 is observed in a wide variety of human malignancies, including gastric cancer. Long-term high dose COX-2 inhibitors can inhibit gastric carcinogenesis in animal models, but the possible life-threatening cardiovascular adverse events limit its popular application. Therefore, it is important to evaluate the optimal intervention point of COX-2 inhibitors for inhibiting H. pylori-associated gastric carcinogenesis.

A research article to be published on October 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Wu from the Department of Gastroenterology of Kaohsiung Medical University Hospital used the Mongolian gerbil model to evaluate the optimal intervention point of COX-2 inhibitor treatment for inhibiting H. pylori-associated gastric carcinogenesis. The article also investigates the possible mechanism of chemoprevention and possible side effects of COX-2 inhibitors.

Previous studies used relatively long-term periods of chemoprevention. However, COX-2 inhibitors were not a placebo and had toxic effects. COX-2 inhibitors should not be used too long for chemoprevention of gastric cancer. According to the findings of this study, Celecoxib may have effects including anti-oncogenic effect, inhibition of angiogenesis and metastasis, and it was shown that these effects were obtained by both late and short-term use of Celecobxib. The protective effect of Celecoxib could involve an early oncogenic phase not an early inflammation phase. The short-term use also resulted in less severe inflammation and inhibited the invasion degree of gastric cancer. According to these findings, Celecoxib could be used latterly and short-term for refractory H. pylori infection in a clinical situation; a point which was seldom discussed in previous reports. This is very important for decreasing the possible side effects of COX-2 inhibitors.

The research team suggests that COX-2 inhibitors should be used as chemoprevention for people older than about forty years old. This chemoprevention may play an important role for people who have extensive metaplastic gastritis with the highest risk for the development of gastric cancer, and it is also very important for those patients with refractory H. pylori infections at high risk of gastric cancer.

A gastroenterological expert said that this result provided some new information about personalized therapy for gastric cancer prevention and would prove beneficial for clinical application in the future.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kuo CH, Hu HM, Tsai PY, Wu IC, Yang SF, Chang LL, Wang JY, Jan CM, Wang WM, Wu DC. Short-term Celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model. World Journal of Gastroenterology, 2009; 15 (39): 4907 DOI: 10.3748/wjg.15.4907

Cite This Page:

World Journal of Gastroenterology. "Is Short-term Celecoxib Intervention A Effective Method For Preventing Gastric Carcinogenesis?." ScienceDaily. ScienceDaily, 28 October 2009. <www.sciencedaily.com/releases/2009/10/091028112611.htm>.
World Journal of Gastroenterology. (2009, October 28). Is Short-term Celecoxib Intervention A Effective Method For Preventing Gastric Carcinogenesis?. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2009/10/091028112611.htm
World Journal of Gastroenterology. "Is Short-term Celecoxib Intervention A Effective Method For Preventing Gastric Carcinogenesis?." ScienceDaily. www.sciencedaily.com/releases/2009/10/091028112611.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins