Featured Research

from universities, journals, and other organizations

Circadian Surprise: Mechanism Of Temperature Synchronization In Drosophila

Date:
October 29, 2009
Source:
Cell Press
Summary:
New research reveals a pathway that links peripheral sensory tissues with a "clock" in the brain to regulate molecular processes and behaviors in response to cyclical temperature changes. The research reveals some surprising fundamental differences between how light-dark and temperature cycles synchronize the brain clock of the fruit fly, Drosophila.

New research reveals a pathway that links peripheral sensory tissues with a "clock" in the brain to regulate molecular processes and behaviors in response to cyclical temperature changes. The research, published by Cell Press in the October 29th issue of the journal Neuron, reveals some surprising fundamental differences between how light-dark and temperature cycles synchronize the brain clock of the fruit fly, Drosophila.

Related Articles


A variety of organisms have evolved an endogenous timing system called a circadian clock to regulate behavioral metabolic activities. "Circadian clocks regulate many biological processes to occur at beneficial times for the organism," explains senior study author, Dr. Ralf Stanewsky from Queen Mary College at the University of London. "Although we know quite a bit about how natural light-dark cycles synchronize the circadian clock of organisms ranging from flies to mammals, little is known about mechanisms of temperature synchronization."

Specifically, it is not known which cells or structures sense temperature changes or how temperature signals reach the brain clock. In an earlier study, Dr. Stanewsky and colleagues identified two mutations in the fruit flies that interfered with temperature synchronization. One of the genes, nocte, was defective in flies that exhibited normal light synchronization but abnormal molecular and behavioral synchronization to temperature.

In the current study, the researchers found that isolated fly brains were able to synchronize to light-dark cycles but were unable to synchronize to temperature cycles. This suggested that in contrast to light-dark synchronization, the brain circadian clock neurons require information from peripheral tissues for temperature synchronization. Importantly, disruption of nocte in peripheral cells also interfered with temperature synchronization.

More specifically, loss of nocte changed the structure and function of major fly sensory organs called chordotonal organs, and had a dramatic influence on temperature synchronization of behavioral activity. Further, other mutants that interfered with the function of the chordotonal organs also disrupted temperature synchronization. This established the chordotonal organs as key circadian temperature receptors.

"Our work reveals surprising and important mechanistic differences between light- and temperature-synchronization and advances our understanding of how clock resetting is accomplished in nature," offers Dr. Stanewsky. "This study demonstrates once again the power of forward genetics in identifying novel factors and mechanisms. Just looking at the nocte DNA sequence, no one would have predicted a function for this gene or the chordotonal organs in temperature synchronization".

The researchers include Hana Sehadova, Queen Mary College, University of London, London, UK; Franz T. Glaser, Institut fur Zoologie, Universitat Regensburg, Regensburg, Germany; Carla Gentile, Queen Mary College, University of London, London, UK; Alekos Simoni, Queen Mary College, University of London, London, UK; Astrid Giesecke, Queen Mary College, University of London, London, UK; Joerg T. Albert, University College London, London, UK; and Ralf Stanewsky, Queen Mary College, University of London, London, UK, Institut fur Zoologie, Universitat Regensburg, Regensburg, Germany.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Circadian Surprise: Mechanism Of Temperature Synchronization In Drosophila." ScienceDaily. ScienceDaily, 29 October 2009. <www.sciencedaily.com/releases/2009/10/091028134624.htm>.
Cell Press. (2009, October 29). Circadian Surprise: Mechanism Of Temperature Synchronization In Drosophila. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2009/10/091028134624.htm
Cell Press. "Circadian Surprise: Mechanism Of Temperature Synchronization In Drosophila." ScienceDaily. www.sciencedaily.com/releases/2009/10/091028134624.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins