Featured Research

from universities, journals, and other organizations

Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring Surgery

Date:
November 11, 2009
Source:
JAMA and Archives Journals
Summary:
Use of the cholesterol-lowering drugs statins for more than a year is associated with a reduced risk of having gallstones requiring surgery, according to a new study.

Use of the cholesterol-lowering drugs statins for more than a year is associated with a reduced risk of having gallstones requiring surgery, according to a study in the November 11 issue of JAMA.

Related Articles


In developed countries, approximately 10 percent to 20 percent of white adults have gallstones, which can cause pain and complications. Gallstone disease is a leading cause of gastrointestinal tract illness and inpatient admission in western countries and represents a serious burden for health care systems worldwide. More than 700,000 cholecystectomies (removal of the gallbladder) are performed annually in the United States, according to background information in the article.

Gallstones are classified as either cholesterol (80 percent-90 percent) or pigment stones (10 percent-20 percent), with cholesterol stones formed on the basis of cholesterol-supersaturated bile. "Statins decrease hepatic [liver] cholesterol biosynthesis and may therefore lower the risk of cholesterol gallstones by reducing the cholesterol concentration in the bile. Data on this association in humans are scarce," the authors write.

Michael Bodmer, M.D., M.Sc., of University Hospital, Basel, Switzerland, and colleagues conducted a large long-term observational study to examine the association between statin use and the risk of developing gallstone disease followed by cholecystectomy. The study included data from between 1994 and 2008 from the UK-based General Practice Research Database. A total of 27,035 patients with cholecystectomy and 106,531 matched controls were identified, including 2,396 patients and 8,868 controls who had statin use.

The researchers found that compared with nonuse, current statin use (last prescription recorded within 90 days before the first-time diagnosis of the disease) was 1.0 percent for patients and 0.8 percent for controls for 1 to 4 prescriptions; 2.6 percent vs. 2.4 percent for 5 to 19 prescriptions, and 3.2 percent vs. 3.7 percent for 20 or more prescriptions.

"This large observational study provides evidence that patients with long-term statin use have a reduced risk of gallstone disease followed by cholecystectomy compared with patients without statin use. However, the odds ratio was not decreased for patients with short-term statin use but started to decrease after 5 prescriptions, reflecting approximately 1 to 1.5 years of treatment. The risk estimate was consistent across age and sex groups. Adjustment for important risk factors for gallstone disease did not materially alter the results," the researchers write.

The authors add that the observed risk reduction suggests a class effect for all statins, and that there was a tendency toward a lower risk of gallstone disease for high-dose statin use compared with low-dose exposure. A substantially increased gallstone risk with cholecystectomy was found for patients with high body mass indexes and for patients with estrogen use.

"Our findings may be of clinical relevance given that gallstone disease represents a major burden for health care systems," the researchers conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael Bodmer; Yolanda B. Brauchli; Stephan Krahenbuhl; Susan S. Jick; Christoph R. Meier. Statin Use and Risk of Gallstone Disease Followed by Cholecystectomy. JAMA, 2009; 302 (18): 2001-2007 [link]

Cite This Page:

JAMA and Archives Journals. "Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring Surgery." ScienceDaily. ScienceDaily, 11 November 2009. <www.sciencedaily.com/releases/2009/11/091110171632.htm>.
JAMA and Archives Journals. (2009, November 11). Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring Surgery. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/11/091110171632.htm
JAMA and Archives Journals. "Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring Surgery." ScienceDaily. www.sciencedaily.com/releases/2009/11/091110171632.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins