Featured Research

from universities, journals, and other organizations

Ventilation treatment in prone position for acute respiratory distress syndrome (ARDS) does not provide significant survival benefit

Date:
November 10, 2009
Source:
JAMA and Archives Journals
Summary:
Despite a current suggestion that patients with acute respiratory distress syndrome be positioned lying face down while receiving mechanical ventilation, research results indicate that this positioning does not significantly lower the risk of death compared to similar patients positioned lying face up during ventilation, according to a new study.

Despite a current suggestion that patients with acute respiratory distress syndrome be positioned lying face down while receiving mechanical ventilation, study results indicate that this positioning does not significantly lower the risk of death compared to similar patients positioned lying face up during ventilation, according to a study in the November 11 issue of JAMA.

Acute respiratory distress syndrome (ARDS) is a serious lung condition with a high mortality rate and may be associated with severe hypoxemia (abnormally low levels of oxygen in the blood, resulting in shortness of breath). Prone positioning is currently suggested for patients with ARDS, for whom various factors makes mechanical ventilation potentially injurious. "Moreover, prone positioning has been advocated as a rescue maneuver for severe hypoxemia, owing to its positive effects on oxygenation, which have been repeatedly documented since its first description in 1976. However, no randomized clinical trial has yet demonstrated a significant reduction in mortality rate associated with prone positioning," the authors write.

Paolo Taccone, M.D., of Fondazione IRCCS-"Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena" di Milano, Milan, Italy, and colleagues conducted a trial to detect the potential survival benefit of prone positioning in patients with moderate and severe hypoxemia who are affected by ARDS. The randomized controlled trial was conducted in 23 centers in Italy and 2 in Spain. The study included 342 adult patients with ARDS receiving mechanical ventilation, enrolled from February 2004 through June 2008 and stratified into subgroups with moderate (n = 192) and severe (n = 150) hypoxemia. Patients were randomized to undergo supine (lying face up; n = 174) or prone (20 hours per day; n = 168) positioning during ventilation.

The researchers found that prone and supine patients from the entire study population had similar 28-day (31.0 percent vs. 32.8 percent) and 6-month (47.0 percent vs. 52.3 percent) mortality rates, despite significantly higher complication rates in the prone group. "Outcomes were also similar for patients with moderate hypoxemia in the prone and supine groups at 28 days (25.5 percent vs. 22.5 percent) and at 6 months (42.6 percent vs. 43.9 percent). The 28-day mortality of patients with severe hypoxemia was 37.8 percent in the prone and 46.1 percent in the supine group, while their 6-month mortality was 52.7 percent and 63.2 percent, respectively."

They authors add that median (midpoint) Sequential Organ Failure Assessment (SOFA) scores, ventilator-free days, and intensive care unit length of stay were also similar between the different groups of patients.

"Do the findings of this trial, together with those of previous studies, represent the end of the prone position technique? Undoubtedly, the data of the present trial together with previous results clearly indicate that prolonged prone positioning, in the unselected ARDS population, is not indicated as a treatment. However, its potential role in patients with the most severe hypoxemia, for whom the possible benefit could outweigh the risk of complications, must be further investigated, considering the strong pathophysiological background, the post hoc result of our previous study, the most recent meta-analysis, and the favorable trend observed prospectively in this study," the authors conclude.

Editorial: Improving Outcomes in Critically Ill Patients

Arthur S. Slutsky, M.D., of St. Michael's Hospital, Toronto, and the University of Toronto, comments on the findings of this study in an accompanying editorial.

"Based on the findings from the trial by Taccone et al combined with data from previous published reports, prone ventilation should not be used routinely in all patients with ARDS. However, for a patient at imminent risk of death from hypoxemia, it makes sense to try prone ventilation, because multiple studies have demonstrated that it can increase oxygenation."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal References:

  1. Taccone et al. Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA The Journal of the American Medical Association, 2009; 302 (18): 1977 DOI: 10.1001/jama.2009.1614
  2. Arthur S. Slutsky. Improving Outcomes in Critically Ill Patients: The Seduction of Physiology. JAMA, 2009; 302 (18): 2030-2032 [link]

Cite This Page:

JAMA and Archives Journals. "Ventilation treatment in prone position for acute respiratory distress syndrome (ARDS) does not provide significant survival benefit." ScienceDaily. ScienceDaily, 10 November 2009. <www.sciencedaily.com/releases/2009/11/091110171639.htm>.
JAMA and Archives Journals. (2009, November 10). Ventilation treatment in prone position for acute respiratory distress syndrome (ARDS) does not provide significant survival benefit. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/11/091110171639.htm
JAMA and Archives Journals. "Ventilation treatment in prone position for acute respiratory distress syndrome (ARDS) does not provide significant survival benefit." ScienceDaily. www.sciencedaily.com/releases/2009/11/091110171639.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins