Featured Research

from universities, journals, and other organizations

Low birth weight and diabetes have a common genetic background

Date:
November 13, 2009
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
Low birth weight increases the risk of developing type 2 diabetes later in life. Until recently scientists had attributed this to maternal malnutrition during pregnancy. However, now it seems that genetic background may also play a major role. Scientists have now demonstrated, that gene variants which influence insulin metabolism can also affect birth weight.

Low birth weight increases the risk of developing type 2 diabetes later in life. Until recently scientists had attributed this to maternal malnutrition during pregnancy. However, now it seems that genetic background may also play a major role. A research team of Technische Universität München and Helmholtz Zentrum München has now demonstrated, that gene variants which influence insulin metabolism can also affect birth weight.

Related Articles


In the BABYDIAB study led by Professor Anette-Gabriele Ziegler, director of the Institut für Diabetesforschung der Forschergruppe Diabetes e.V. at Helmholtz Zentrum München and Forschergruppe Diabetes at the Technische Universität München analyzed the data of 729 children whose mothers had type 1 diabetes and who thus had a higher diabetes risk.

The scientists investigated the genetic background of fetuses for alterations in individual DNA bases, termed single nucleotide polymorphisms (SNPs). Here they focused on three gene regions which are known to be risk alleles for diabetes caused by reduced insulin secretion. They looked at these in relation to birth weight.

It turned out that there was a significant association between the two SNPs of the HHEX-IDE gene region and low birth weight. This was independent of HbA1c levels (long-term blood glucose levels) of the expectant mother, indicating a lesser correlation between maternal nutrition and blood glucose regulation. "Interestingly, we found this effect in children whose mothers had type 1 diabetes. This could mean that an a priori reduced insulin secretion also plays a role in the development of autoimmune type 1 diabetes," explained Dr. Christiane Winkler of the Forschergruppe Diabetes at Helmholtz Zentrum München and first author of the publication.

In contrast, the researchers found no correlation between the two SNPs of the other gene regions that were studied (CDKAL1 and SLC30A8) and birth weight. However, this does not entirely exclude an association -- such an effect could become apparent with higher numbers of participants. "Indications of genetic associations are usually only found in very large populations. As we see here, it is important to substantiate these in smaller, but very well-phenotyped study populations. We can thus gain information about the possible mechanism of the original results," emphasized PD Dr. Thomas Illig, head of the Epidemiology -- Biological Samples -- Genomics research unit at Helmholtz Zentrum München.

With their findings, the Munich researchers have come a step closer to understanding the underlying genetic mechanisms of diabetes diseases. "Next, we want to investigate whether the genetic associations observed in this study could also have an effect on body weight later in life. Due to the long-term BABYDIAB study, which has run continuously since 1989, this data already exists," Christiane Winkler explained.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Winkler et al. HHEX-IDE Polymorphism Is Associated with Low Birth Weight in Offspring with a Family History of Type 1 Diabetes. Journal of Clinical Endocrinology & Metabolism, 2009; 94 (10): 4113 DOI: 10.1210/jc.2009-0970

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Low birth weight and diabetes have a common genetic background." ScienceDaily. ScienceDaily, 13 November 2009. <www.sciencedaily.com/releases/2009/11/091112191513.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2009, November 13). Low birth weight and diabetes have a common genetic background. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2009/11/091112191513.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Low birth weight and diabetes have a common genetic background." ScienceDaily. www.sciencedaily.com/releases/2009/11/091112191513.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) — A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) — Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins