Featured Research

from universities, journals, and other organizations

Genetic changes shown to be important indicators for disease progression in cervical cancer patients

Date:
November 15, 2009
Source:
Public Library of Science
Summary:
Cervical cancer patients with specific changes in the cancer genome have a three- or fourfold increased risk of relapse after standard treatment compared to patients without these changes, according to a new study. The research suggests that specific genetic changes are crucial steps in the progression of the disease towards an aggressive and treatment-resistant state.

Cervical cancer patients with specific changes in the cancer genome have a three- or fourfold increased risk of relapse after standard treatment compared to patients without these changes, according to a study by Norwegian researchers published November 13 in the open-access journal PLoS Genetics. The research suggests that specific genetic changes are crucial steps in the progression of the disease towards an aggressive and treatment-resistant state.

Cervical cancer is one of the most common malignancies affecting women worldwide and a major cause of cancer-related death. The researchers therefore sought to explore whether these genetic changes could add information to clinical data obtained through standard examination methods, and be used to identify patients who need additional treatment. Previous studies have shown that the cancer cells of cervical cancer patients display numerous genetic changes, but their importance for disease progression and treatment resistance has not been clear.

The authors, led by Heidi Lyng, examined more than 140 patients diagnosed and treated at the Norwegian Radium Hospital. Through the use of screening methods that covered all genes in the human genome, the researchers report as their key finding the discovery of a set of biological processes that are known hallmarks of cancer associated with gains and losses of specific genes. Moreover, they identify novel loci associated with resistance to chemo- and radiotherapy, and depict the genes involved.

This research represents an important step in understanding the development of cervical cancer, but the authors emphasize that the results need to be validated in independent patient cohorts before they can be considered for use in clinical decision making.

The study was supported by The National Programme for Research in Functional Genomics (FUGE) in the Research Council of Norway, The Norwegian Cancer Society, and the South-Eastern Norway Regional Health Authority.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lando et al. Gene Dosage, Expression, and Ontology Analysis Identifies Driver Genes in the Carcinogenesis and Chemoradioresistance of Cervical Cancer. PLoS Genetics, 2009; 5 (11): e1000719 DOI: 10.1371/journal.pgen.1000719

Cite This Page:

Public Library of Science. "Genetic changes shown to be important indicators for disease progression in cervical cancer patients." ScienceDaily. ScienceDaily, 15 November 2009. <www.sciencedaily.com/releases/2009/11/091113083309.htm>.
Public Library of Science. (2009, November 15). Genetic changes shown to be important indicators for disease progression in cervical cancer patients. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/11/091113083309.htm
Public Library of Science. "Genetic changes shown to be important indicators for disease progression in cervical cancer patients." ScienceDaily. www.sciencedaily.com/releases/2009/11/091113083309.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins