Featured Research

from universities, journals, and other organizations

'Cross-talk' mechanism contributes to colorectal cancer

Date:
November 16, 2009
Source:
University of Wisconsin-Madison
Summary:
Researchers have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.

Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.

Related Articles


"We are very excited about these findings," says Vladimir Spiegelman, an associate professor of dermatology. "Drugs could be developed to block this mechanism and prevent colorectal cancer, which affects millions of people worldwide."

The research will appear in the November 15 issue of Cancer Research.

Spiegelman and his team study cellular processes that produce several types of cancer. They have focused recently on the Wnt signaling pathway, which has been implicated in the vast majority of all colorectal cancers.

Like all signaling pathways, this one involves a group of molecules that work in sequence to perform a specific cell function. At each step along the way, the molecules perform tasks outlined in the signals until the job is finally done. If there's a breakdown anywhere in the normal process, cancer can occur.

In an earlier paper published in Nature, Spiegelman's team described how signals in the Wnt pathway regulate CRD-BP, a gene that contributes to normal colorectal cells' changing into tumor cells.

"Within the Wnt pathway, we found that CRD-BP binds to and increases the messenger RNA of a cancer-promoting transcription factor called GLI1," Spiegelman explains.

The scientists knew that GLI1 was also active in another signaling pathway, called Hedgehog, which is known to be associated with the development of several kinds of cancers although its role in colorectal cancer has been controversial. So they explored how the two pathways interact around CRD-BP and GLI1 messenger RNA.

"Scientists have postulated that these two pathways engage in cross-talk in different ways, but the mechanisms of how and where that happens have been unclear," Spiegelman says. Each pathway, he adds, contributes in important ways to normal embryonic development and stem-cell maintenance.

The team found that CRD-PB serves as the link between the Wnt and Hedgehog pathways.

From the Wnt pathway, CRD-PB imposes itself on the Hedgehog pathway, stabilizing and dramatically increasing the expression of GLI1 messenger RNA there.

"This occurs irrespective of what happens upstream in the Hedgehog pathway," says Spiegelman. "Hedgehog signaling is not necessary for this to occur, even though the outcome mimics the activation of the Hedgehog pathway."

Increased GLI1 then activates cancer-promoting genes that are usually considered downstream targets of the Hedgehog pathway. The findings point to promising therapeutic possibilities, says Spiegelman.

"GLI1 by itself could be an excellent target for a potential blocking drug," he says. "But if we go upstream and target CRD-PB, we can affect the two different signaling pathways even more effectively."


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.


Cite This Page:

University of Wisconsin-Madison. "'Cross-talk' mechanism contributes to colorectal cancer." ScienceDaily. ScienceDaily, 16 November 2009. <www.sciencedaily.com/releases/2009/11/091114080606.htm>.
University of Wisconsin-Madison. (2009, November 16). 'Cross-talk' mechanism contributes to colorectal cancer. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2009/11/091114080606.htm
University of Wisconsin-Madison. "'Cross-talk' mechanism contributes to colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2009/11/091114080606.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins