Featured Research

from universities, journals, and other organizations

Nutrigenomics researchers replicate gene interaction with saturated fat

Date:
November 19, 2009
Source:
Tufts University, Health Sciences
Summary:
Rsearchers have identified a gene-diet interaction that appears to influence body weight and have replicated their findings in three independent studies. Men and women carrying the CC genotype demonstrated higher body mass index scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat. These associations were seen in the apolipoprotein A-II gene promoter.

Tufts University researchers have identified a gene-diet interaction that appears to influence body weight and have replicated their findings in three independent studies. Men and women carrying the CC genotype demonstrated higher body mass index (BMI) scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat. These associations were seen in the apolipoprotein A-II gene (APOA2) promoter.

"We believe this is the first time a gene-diet interaction influencing BMI and obesity has been replicated in as many as three independent study populations," said corresponding and senior author Jose Ordovas, PhD, director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts. "Our findings strengthen support for the science of nutrigenomics and are another step toward the goal of individually tailoring dietary recommendations to lower risk of chronic disease or conditions like obesity."

The study, published in the November 9 issue of Archives of Internal Medicine, examines gene-diet interactions in the APOA2 promoter, a region of DNA controlling expression of the APOA2 gene. Proteins responding to some nutrients in food interact with promoters which dictate how genes behave. There are two variants or alleles of the APOA2 promoter, T and C. They exist in three genotypes: CC, TT and TC.

Ordovas and colleagues studied these genotypes in 3,462 men and women who participated in the Framingham Offspring Study (FOS), the Genetics of Lipid Lowering Drugs and Diet Network Study (GOLDN) and the Boston-Puerto Rican Centers on Population and Health Disparities Study (Boston- Puerto Rican Study). FOS and GOLDN enrolled Caucasian adults. The Boston-Puerto Rican Study is comprised of Puerto Rican men and women. "We are further encouraged that our findings were replicated in diverse populations," said Ordovas, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts.

The researchers divided the study population into high and low saturated fat groups. Next, they compared saturated fat intake, BMI and obesity risk across the CC, TT and TC genotypes. High saturated fat intake was defined as 22 grams or more per day. Foods such as fatty cuts of meat and dairy products made with whole or 2 % milk contain saturated fat, which raises cholesterol. CC carriers who consumed high levels of saturated fat were the most susceptible to higher BMI and obesity, Ordovas and colleagues observed.

"Across all three studies, the CC carriers who consumed high-saturated fat diets had the highest BMIs compared to the TT and TC genotypes and, most notably, other CC carriers who reported consuming low-saturated fat diets," said first author Dolores Corella, PhD, Professor at the Valencia University-CIBER Fisiopatología de la Obesidad y Nutrición (Spain), and visiting scientist in the Nutrition and Genomics Laboratory at the USDA HNRCA. "This work is based on a two year-old study finding genotypes influence food preferences, calorie intake and BMI."

In the previous study, Ordovas, Corella and colleagues found men and women with the CC genotype had a statistically significant higher intake of fat than the TT and TC genotype groups. Additionally, CC carriers ate about 200 more calories per day and were about twice as likely to be obese.

The authors saw the same results for obesity prevalence within the CC genotype in the present study. "We saw a strong association between obesity and high saturated-fat intake, but again, there was no significant association between the two in CC carriers with low saturated-fat intake or in TT or TC carriers," Corella added.

Obesity was defined as BMI of 30 or greater. The researchers calculated BMI as weight in kilograms divided by height in meters squared. Dietary intake was measured by self-reported dietary questionnaires.

As in the general population, the majority of study participants possessed the TT and TC genotypes. Approximately 10 to 15 percent of the United States population is CC carriers, which was reflected in the FOS, GOLDN and Boston Puerto-Rican Study.

"Although CC carriers are only a small portion of the population, we believe the interaction we observed between saturated fat and BMI merits further investigation," Ordovas said. "There is a need to understand the mechanisms behind this particular diet-gene interaction and to find out whether other there are similar interactions in other genes that could factor in obesity prevention."

This work was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, National Heart, Lung and Blood Institute, National Institute on Aging, the USDA Agriculture Research Service (ARS), the Ministerio de Ciencia e Innovacion, the Instituto de Salud Carlos III and the CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain.

Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai C, Parnell LD, Coltell O, Lee Y and Ordovas JM. Arch Intern Med . (Nov. 9, 2009); vol. 169 (20): 1897-1906. "APOA2, Dietary Fat and Body Mass Index."


Story Source:

The above story is based on materials provided by Tufts University, Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

Tufts University, Health Sciences. "Nutrigenomics researchers replicate gene interaction with saturated fat." ScienceDaily. ScienceDaily, 19 November 2009. <www.sciencedaily.com/releases/2009/11/091117102038.htm>.
Tufts University, Health Sciences. (2009, November 19). Nutrigenomics researchers replicate gene interaction with saturated fat. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/11/091117102038.htm
Tufts University, Health Sciences. "Nutrigenomics researchers replicate gene interaction with saturated fat." ScienceDaily. www.sciencedaily.com/releases/2009/11/091117102038.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins