Featured Research

from universities, journals, and other organizations

New therapy may be effective against bacterial infections and sepsis

Date:
November 29, 2009
Source:
American Society for Microbiology
Summary:
A new study found that certain immune cells primarily associated with asthma and allergies may enhance innate immunity and improve clearance of bacterial infections and may be an effective new therapy against bacterial infections and sepsis in humans.

A new study found that certain immune cells primarily associated with asthma and allergies may enhance innate immunity and improve clearance of bacterial infections and may be an effective new therapy against bacterial infections and sepsis in humans. The researchers from Oregon Health and Science University, Portland and the Mayo Clinic, Scottsdale, Arizona report their findings in the November 2009 issue of the journal Infection and Immunity.

Related Articles


Sepsis, the systemic inflammatory response to infection, affects more than 700,000 people annually in the U.S. alone and is the leading cause of death in the intensive care unit. Ninety percent of reported cases are attributed to bacterial infections and mortality rates remain at 25% despite high quality supportive care and antibiotic treatment. Innate immune responses are vital to containing bacterial pathogens and recent studies link sepsis with impaired immunity. Antibiotic resistance and an increase in the mortality rate of sepsis patients due to the use of inappropriate antibiotics, as well as the role of the innate immune response in pathogen control highlight the need for new antimicrobial therapies.

Eosinophils are white blood cells whose normal function is to protect the body against parasitic infections. They are also commonly associated with asthma and allergies. Numerous prior studies have noted the presence of Toll-like receptors (TLRs) on the surfaces of eosinophils indicating that they may play a part in recognizing and killing viruses and bacteria. In the study researchers found that isolated mouse eosinophils possessed antibacterial properties against Pseudomonas aeruginosa in vitro. In vivo, transgenic mice demonstrating high levels of eosinophils, showed improved clearance of P. aeruginosa, whereas bacterial clearance was impaired in mice with a congenital eosinophil deficiency suggesting an eosinophil specific effect.

"We provide evidence that mouse eosinophils and eosinphil granules play a beneficial but poorly defined role in innate immune responses to bacterial infections," say the researchers. "Moreover, the data suggest that the administration of eosinophil-derived products may represent a viable adjuvant therapy for septic or bacteremic patients in the intensive care unit."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S.N. Linch, A.M. Kelly, E.T. Danielson, R. Pero, J.J. Lee, J.A. Gold. Mouse Eosinophils Possess Potent Antibacterial Properties In Vivo. Infection and Immunity, 2009; 77 (11): 4976 DOI: 10.1128/IAI.00306-09

Cite This Page:

American Society for Microbiology. "New therapy may be effective against bacterial infections and sepsis." ScienceDaily. ScienceDaily, 29 November 2009. <www.sciencedaily.com/releases/2009/11/091119212126.htm>.
American Society for Microbiology. (2009, November 29). New therapy may be effective against bacterial infections and sepsis. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2009/11/091119212126.htm
American Society for Microbiology. "New therapy may be effective against bacterial infections and sepsis." ScienceDaily. www.sciencedaily.com/releases/2009/11/091119212126.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins