Featured Research

from universities, journals, and other organizations

Microbes help mothers protect kids from allergies

Date:
December 28, 2009
Source:
Rockefeller University Press
Summary:
A pregnant woman's exposure to microbes may protect her child from developing allergies later in life. Researchers in Germany find that exposure to environmental bacteria triggers a mild inflammatory response in pregnant mice that renders their offspring resistant to allergies.

A pregnant woman's exposure to microbes may protect her child from developing allergies later in life. Researchers in Marburg, Germany find that exposure to environmental bacteria triggers a mild inflammatory response in pregnant mice that renders their offspring resistant to allergies.

Related Articles


The study will be published online on December 7, 2009 in the Journal of Experimental Medicine. In an accompanying Commentary, Patrick Holt and Deborah Strickland discuss the biological mechanisms behind these findings and how they might one day prevent allergies in people.

The progressive rise in allergies in the past several decades is often attributed to an increasing tendency to keep kids too clean -- a theory known as the hygiene hypothesis. According to this theory, exposure of young children to environmental microbes conditions the developing immune system to tolerate microbes and allergens later in life. Studies have shown, for example, that children raised on farms, which teem with microbes, developed fewer allergies than those raised in cities or non-farming rural regions. But it may not be the kids' exposure that counts; children of farming mothers are also less susceptible to allergies regardless of their own exposure. But the biological mechanisms behind this phenomenon were a mystery.

According to the new study by Harald Renz and colleagues at the Phillips-University of Marburg, pregnant mice exposed to inhaled barnyard microbes gave birth to allergy-resistant pups. The exposure triggered a mild inflammatory response in the moms, characterized by the increased expression of microbe-sensing "Toll-like" receptors (TLRs) and the production of immune molecules called cytokines. The maternal TLRs were essential for transmitting protection, but how TLR signals translate into allergy resistance in the offspring is not yet known. It also remains to be seen whether the protection applies to a broad range of allergens, including those found in food.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal References:

  1. Conrad, M.L., et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J. Exp. Med., 2009; DOI: 10.1084/jem.20090845
  2. Holt, P.G., and D.H. Strickland. Soothing signals: transplacental transmission of resistance to asthma and allergy. J. Exp. Med., 2009; DOI: 10.1084/jem.20092469

Cite This Page:

Rockefeller University Press. "Microbes help mothers protect kids from allergies." ScienceDaily. ScienceDaily, 28 December 2009. <www.sciencedaily.com/releases/2009/12/091207095459.htm>.
Rockefeller University Press. (2009, December 28). Microbes help mothers protect kids from allergies. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/12/091207095459.htm
Rockefeller University Press. "Microbes help mothers protect kids from allergies." ScienceDaily. www.sciencedaily.com/releases/2009/12/091207095459.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins