Featured Research

from universities, journals, and other organizations

Gene positions may aid cancer diagnosis, study shows

Date:
December 8, 2009
Source:
Rockefeller University Press
Summary:
Certain genes switch their nuclear position in tumor cells, offering a potential new method of diagnosing cancer, say researchers.

Certain genes switch their nuclear position in tumor cells, offering a potential new method of diagnosing cancer, say researchers from the National Cancer Institute.

The study by Meaburn et al. will be published online December 7, 2009 and in the December 14, 2009 print issue of the Journal of Cell Biology (JCB).

Individual genes preferentially localize to specific points within the nucleus. The reasons for this aren't known, but the positions can be reshuffled during differentiation. Meaburn et al. wondered whether genes might also rearrange during carcinogenesis, when large-scale changes in nuclear morphology occur. The researchers previously identified four genes that shift their location in a 3D culture model of early breast cancer, and now turned their attention to human tissue.

The team analyzed 20 genes and found that most were positioned uniformly in healthy breast tissue from numerous individuals. Eight of these genes consistently relocated in the nuclei of invasive breast cancer cells, including HES5, which had an altered localization in all tumors examined. The researchers were able to distinguish between normal and diseased tissue on the sole basis of these genes' nuclear localization with success rates similar to current clinical tests.

The next step, says lead author Karen Meaburn, will be to repeat the study on a larger number of samples. HES5 is unlikely to be repositioned in all of these, so the authors hope to identify a set of genes that, in combination, can accurately diagnose breast cancer. The approach may be useful for prognosis, too -- in vitro studies suggest that gene movements are an early event in cancer development, so gene positions might provide an indication of the cancer's future progress.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Meaburn, K.J., et al. Disease-specific gene repositioning in breast cancer. J. Cell Biol., 2009; DOI: 10.1083/jcb.200909127

Cite This Page:

Rockefeller University Press. "Gene positions may aid cancer diagnosis, study shows." ScienceDaily. ScienceDaily, 8 December 2009. <www.sciencedaily.com/releases/2009/12/091207095501.htm>.
Rockefeller University Press. (2009, December 8). Gene positions may aid cancer diagnosis, study shows. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2009/12/091207095501.htm
Rockefeller University Press. "Gene positions may aid cancer diagnosis, study shows." ScienceDaily. www.sciencedaily.com/releases/2009/12/091207095501.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins