Featured Research

from universities, journals, and other organizations

Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients

Date:
December 11, 2009
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
Eighteen single-point genetic variations indicate risk of recurrence for early-stage head and neck cancer patients and their likelihood of developing a second type of cancer, researchers report.

Eighteen single-point genetic variations indicate risk of recurrence for early-stage head and neck cancer patients and their likelihood of developing a second type of cancer, researchers at The University of Texas M. D. Anderson Cancer Center reported at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.

Related Articles


The team examined 241 single nucleotide polymorphisms -- variations of a single DNA building block in a gene -- in eight genes involved in the creation of micro RNA (miRNA), small bits of RNA that regulate genes, and 130 miRNA binding sites on host genes where miRNAs exert their effects on regulating gene expression.

"We focus on miRNA pathways because these small molecules regulate between one third and half of genes," said senior author Xifeng Wu, M.D., Ph.D., professor in M. D. Anderson's Department of Epidemiology in the Division of Cancer Prevention and Population Sciences.

"Genetic variations in miRNA biogenesis genes and miRNA binding sites have been associated with the risk of having multiple solid tumors, so we hypothesized that these variations might be associated with the risk of recurrence or secondary primary tumors in these patients," Wu said.

About 10 percent of patients have a recurrence, and 15-25 percent go on to develop secondary primary tumors.

The team conducted a case-control study of 150 patients with recurrence or a second cancer and 300 patients without either. They found eighteen SNPs to be associated with recurrence/secondary cancer risk, including eleven SNPs in three miRNA biogenesis genes and seven in miRNA binding sites. Eight of the significant SNPs were in RNASEN gene, one of which was associated with a 72 percent increase in risk.

Compared to patients with fewer than four unfavorable genotypes, patients with five to nine unfavorable genotypes have a 2.4-fold increased risk and those with more than ten a 7.7-fold rise in risk.

Additional analysis of gene-gene interaction characterized the study patients into risk groups. The low-risk group had an event-free median survival time of more than 93 months. The highest-risk group had five times the risk of the low-risk group, and an event-free median survival of 35.9 months.

"Our results suggest that genetic variations in the miRNA biogenesis pathway and miRNA binding sites may be used to predict the risk of recurrence or secondary primary tumor in head and neck cancer patients," said first author Xiaofan Zhang, Ph.D., a postdoctoral fellow in epidemiology.

The project was funded by grants from the National Cancer Institute.

Co-authors with Zhang and Wu are Hushan Yang, Ph.D., and Margaret Spitz, M.D., of the department of Epidemiology; J. Jack Lee, Ph.D., of M. D. Anderson's Department of Biostatistics; Edward Kim, M.D., Scott Lippman, M.D., and Reuben Lotan, Ph.D., of M.D. Anderson's Department of Thoracic/Head and Neck Medical Oncology; Waun Ki Hong, M.D., head of the Division of Cancer Medicine.


Story Source:

The above story is based on materials provided by University of Texas M. D. Anderson Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Texas M. D. Anderson Cancer Center. "Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients." ScienceDaily. ScienceDaily, 11 December 2009. <www.sciencedaily.com/releases/2009/12/091207143345.htm>.
University of Texas M. D. Anderson Cancer Center. (2009, December 11). Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/12/091207143345.htm
University of Texas M. D. Anderson Cancer Center. "Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients." ScienceDaily. www.sciencedaily.com/releases/2009/12/091207143345.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins