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New platinum compound shows promise in tumor cells

Date:
December 8, 2009
Source:
Massachusetts Institute of Technology
Summary:
Chemists have developed a new platinum compound that is as powerful as the commonly used anticancer drug cisplatin but better able to destroy tumor cells.

A diagram of cisplatin.
Credit: Image courtesy of Massachusetts Institute of Technology

MIT chemists have developed a new platinum compound that is as powerful as the commonly used anticancer drug cisplatin but better able to destroy tumor cells.

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The new compound, mitaplatin, combines cisplatin with another compound, dichloroacetate (DCA), which can alter the properties of mitochondria selectively in cancer cells. Cancer cells switch their mitochondrial properties to change the way they metabolize glucose compared to normal cells, and DCA specifically targets the altered mitochondria, leaving normal cells intact.

"This differential effect conveys on mitaplatin the ability to kill cancer cells selectively in a co-culture with normal fibroblast cells, the latter being unaffected at the doses that we apply," says Stephen Lippard, the Arthur Amos Noyes Professor of Chemistry.

How they did it: The chemists designed mitaplatin so that when it enters a cell, it releases cisplatin and two units of DCA by intracellular reduction. Therefore, mitaplatin can attack nuclear DNA with cisplatin and mitochondria with DCA. DCA promotes the release of cell-death-promoting factors from the mitochondria, enhancing the cancer cell-killing abilities of cisplatin.

Next steps: Lippard's laboratory has shown that in rodents, mitaplatin can be tolerated at much higher doses than cisplatin, and they have begun studies in mice transplanted with human tissues. If those results are promising, the researchers plan more studies for further demonstration of mitaplatin's ability in cancer therapy.


Story Source:

The above story is based on materials provided by Massachusetts Institute of Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shanta Dhar and Stephen Lippard. Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate. Proceedings of the National Academy of Sciences, Week of Dec. 7, 2009

Cite This Page:

Massachusetts Institute of Technology. "New platinum compound shows promise in tumor cells." ScienceDaily. ScienceDaily, 8 December 2009. <www.sciencedaily.com/releases/2009/12/091207151226.htm>.
Massachusetts Institute of Technology. (2009, December 8). New platinum compound shows promise in tumor cells. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2009/12/091207151226.htm
Massachusetts Institute of Technology. "New platinum compound shows promise in tumor cells." ScienceDaily. www.sciencedaily.com/releases/2009/12/091207151226.htm (accessed November 20, 2014).

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