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Genetic link to heart failure

Date:
January 1, 2010
Source:
Journal of Clinical Investigation
Summary:
New research has identified a group of 12 genetic variants in the HSPB7 gene that is associated with heart failure in humans.

A team of researchers, at Washington University School of Medicine, St Louis, has identified a group of 12 genetic variants in the HSPB7 gene that is associated with heart failure in humans.

The research is reported in the Journal of Clinical Investigation.

The team, led by Gerald Dorn, used an approach they have recently developed that allows ultra-high-throughput targeted DNA sequencing to identify genetic variation in four genes with biological relevance to heart failure. They identified in a large group of Caucasian individuals with heart failure, 129 separate genetic variants in the four genes, including 23 that seemed to be novel.

Further analysis of 1117 Caucasian individuals with heart failure and 625 nonaffected Caucasians indicated that a block of 12 genetic variants in the HSPB7 gene was associated with heart failure. Confirmation of this association was provided by analysis of an independent group of individuals.

The authors hope to use the same approach to identify further genetic variants associated with heart failure, a disease that is influenced by multiple genetic factors.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Scot J. Matkovich, Derek J. Van Booven, Anna Hindes, Min Young Kang, Todd E. Druley, Francesco L.m. Vallania, Robi D. Mitra, Muredach P. Reilly, Thomas P. Cappola and Gerald W. Dorn, II. Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39085

Cite This Page:

Journal of Clinical Investigation. "Genetic link to heart failure." ScienceDaily. ScienceDaily, 1 January 2010. <www.sciencedaily.com/releases/2009/12/091214173516.htm>.
Journal of Clinical Investigation. (2010, January 1). Genetic link to heart failure. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/12/091214173516.htm
Journal of Clinical Investigation. "Genetic link to heart failure." ScienceDaily. www.sciencedaily.com/releases/2009/12/091214173516.htm (accessed October 1, 2014).

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