Featured Research

from universities, journals, and other organizations

Fight infection by disturbing how bacteria communicate

Date:
December 24, 2009
Source:
University of Groningen
Summary:
Researchers have clarified the structure of an enzyme that disturbs the communication processes between bacteria. By doing so they have laid the foundations for a new method of tackling bacterial infections such as cystic fibrosis.

Researchers from the University of Groningen have clarified the structure of an enzyme that disturbs the communication processes between bacteria. By doing so they have laid the foundations for a new method of tackling bacterial infections such as cystic fibrosis. An article on the structure and function of the so-called quorum-quenching acylase was published on 21 December 2009 in the online edition of the Proceedings of the National Academy of Sciences of the United States of America (PNAS).

Although bacteria are simple single-celled organisms, they are capable of communicating with each other. Bacteria talk to each other by exchanging tiny hormone-like signal molecules. By means of this process of 'quorum sensing', the activities of a large group of bacteria are synchronized. Thus bacteria can adapt quickly to changes in their environment such as the running out of nutrients or the arrival of rival microorganisms.

The production of factors that determine the virulence of a bacterium is also controlled by these signal molecules. This enables bacteria to remain invisible to the immune system in the early stages of infection. As soon as the group of informed bacteria -- the quorum -- is sufficiently large, the attack on the infected host is initiated by starting up the production of toxins and other virulence factors.

The quorum-quenching acylase of which the Groningen research team has determined the structure is capable of cutting off these signal molecules. As a result, the communication processes between pathogenic bacteria are disturbed. The enzyme turns out to suppress the virulence of the lung bacteria Pseudomonas aeruginosa, the most important pathogen for cystic fibrosis.

The clarified structure of the bacterial jammer provides insight into the precise functioning of the acylase and could be the first step in the development of a new antibacterial therapy.


Story Source:

The above story is based on materials provided by University of Groningen. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bokhove, M., Nadal Jimenez, P., Quax, W.J. and B. W. Dijkstra. The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket. Proceedings of the National Academy of Sciences of the United States of America, 2009-11839R Early Edition

Cite This Page:

University of Groningen. "Fight infection by disturbing how bacteria communicate." ScienceDaily. ScienceDaily, 24 December 2009. <www.sciencedaily.com/releases/2009/12/091221130216.htm>.
University of Groningen. (2009, December 24). Fight infection by disturbing how bacteria communicate. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2009/12/091221130216.htm
University of Groningen. "Fight infection by disturbing how bacteria communicate." ScienceDaily. www.sciencedaily.com/releases/2009/12/091221130216.htm (accessed September 1, 2014).

Share This




More Plants & Animals News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins