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Why diseased heart muscle cells don't communicate properly

Date:
December 31, 2009
Source:
Journal of Clinical Investigation
Summary:
The heartbeat is controlled by rapid conduction of an electrical current between heart muscle cells. Central to passage of the electrical current are structures known as gap junctions, low resistance conduits that link heart muscle cells and consist of proteins known as connexins.

The heartbeat is controlled by rapid conduction of an electrical current between heart muscle cells. Central to passage of the electrical current are structures known as gap junctions, low resistance conduits that link heart muscle cells and consist of proteins known as connexins.

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Many forms of heart disease are associated with decreased gap junction coupling, and these changes predispose to abnormal heartbeats, which can be lethal. Robin Shaw and colleagues, at the University of California at San Francisco, have now identified a reason why there is decreased gap junction coupling in these situations using human, mouse, and zebrafish heart tissue.

The research appears in the Journal of Clinical Investigation.

In the study, the protein EB1, which delivers connexins to gap junctions, was found to be displaced in ischemic human hearts, stressed mouse hearts, and isolated cells subjected to oxidative stress, leading to decreased gap junction coupling. Further, in zebrafish hearts, oxidative stress reduced the membrane localization of connexin and slowed the spread of electrical currents.

The authors hope that developing approaches to preserve the ability of cells to transport connexins to the cell surface to form gap junctions might reduce potentially lethal abnormal heartbeats in humans with diseased hearts.

In an accompanying commentary, Gordon Tomaselli, at Johns Hopkins University School of Medicine, Baltimore, discusses the importance of maintaining normal gap junction function in the heart and explains how the work of Shaw and colleagues fits into the complex puzzle that is our understanding of how heart muscle cells communicate.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. James W. Smyth, Ting-Ting Hong, Danchen Gao, Jacob M. Vogan, Brian C. Jensen, Tina S. Fong, Paul C. Simpson, Didier Y.r. Stainier, Neil C. Chi, and Robin M. Shaw. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. Journal of Clinical Investigation, Published December 28, 2009 DOI: 10.1172/JCI39740
  2. Gordon F. Tomaselli. Oxidant stress derails the cardiac connexon connection. Journal of Clinical Investigation, 2010; 120 (1): 87-89 DOI: 10.1172/JCI41780

Cite This Page:

Journal of Clinical Investigation. "Why diseased heart muscle cells don't communicate properly." ScienceDaily. ScienceDaily, 31 December 2009. <www.sciencedaily.com/releases/2009/12/091228171858.htm>.
Journal of Clinical Investigation. (2009, December 31). Why diseased heart muscle cells don't communicate properly. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2009/12/091228171858.htm
Journal of Clinical Investigation. "Why diseased heart muscle cells don't communicate properly." ScienceDaily. www.sciencedaily.com/releases/2009/12/091228171858.htm (accessed October 30, 2014).

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