Featured Research

from universities, journals, and other organizations

Targeting cancerous vessels

Date:
January 10, 2010
Source:
Rockefeller University Press
Summary:
By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival.

Vascular endothelial cells (green) express {delta}-catenin (red).
Credit: DeBusk, L.M., et al. 2010. J. Exp. Med. doi:10.1084/jem.20091097

By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival.

Related Articles


The findings are reported online in the Journal of Experimental Medicine on Jan. 4, 2010.

Formerly known for its effects on neuronal growth, the team found that the protein δ-catenin is also produced by cells in human blood vessels. By diminishing δ-catenin expression, the team disrupted vessel development, or angiogenesis, associated with inflammation in tumors and wounds. As expected, samples of human lung tumors expressed more δ-catenin than the surrounding tissues. And normal angiogenesis remained the same regardless of δ-catenin.

Because blocking δ-catenin stunts only inflammation-induced angiogenesis, the protein may be a promising anti-cancer target, says Charles Lin, an author on the study at Vanderbilt University Medical Center in Tennessee.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laura M. DeBusk, Kimberly Boelte, Yongfen Min, and P. Charles Lin. Heterozygous deficiency of δ-catenin impairs pathological angiogenesis. Journal of Experimental Medicine, January 4, 2010 DOI: 10.1084/jem.20091097

Cite This Page:

Rockefeller University Press. "Targeting cancerous vessels." ScienceDaily. ScienceDaily, 10 January 2010. <www.sciencedaily.com/releases/2010/01/100104091128.htm>.
Rockefeller University Press. (2010, January 10). Targeting cancerous vessels. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2010/01/100104091128.htm
Rockefeller University Press. "Targeting cancerous vessels." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104091128.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
New FDA-Approved Diabetes Medicine Might Save Drugmaker

New FDA-Approved Diabetes Medicine Might Save Drugmaker

Newsy (Feb. 26, 2015) The U.S. Food and Drug Administration approved new diabetes drug Toujeo on Wednesday, a move that might save French drugmaker Sanofi&apos;s profits. Video provided by Newsy
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The 5 Best Tips to Look Younger Now

The 5 Best Tips to Look Younger Now

Buzz60 (Feb. 26, 2015) Life happens, and we all get older, but forget the pricey anti-aging products and plastic surgery. You can tweak your habits to turn back the hands of time. Krystin Goodwin (@krystingoodwin) has a few simple tips to help you look and feel younger. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins