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Targeting cancerous vessels

Date:
January 10, 2010
Source:
Rockefeller University Press
Summary:
By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival.

Vascular endothelial cells (green) express {delta}-catenin (red).
Credit: DeBusk, L.M., et al. 2010. J. Exp. Med. doi:10.1084/jem.20091097

By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival.

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The findings are reported online in the Journal of Experimental Medicine on Jan. 4, 2010.

Formerly known for its effects on neuronal growth, the team found that the protein δ-catenin is also produced by cells in human blood vessels. By diminishing δ-catenin expression, the team disrupted vessel development, or angiogenesis, associated with inflammation in tumors and wounds. As expected, samples of human lung tumors expressed more δ-catenin than the surrounding tissues. And normal angiogenesis remained the same regardless of δ-catenin.

Because blocking δ-catenin stunts only inflammation-induced angiogenesis, the protein may be a promising anti-cancer target, says Charles Lin, an author on the study at Vanderbilt University Medical Center in Tennessee.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laura M. DeBusk, Kimberly Boelte, Yongfen Min, and P. Charles Lin. Heterozygous deficiency of δ-catenin impairs pathological angiogenesis. Journal of Experimental Medicine, January 4, 2010 DOI: 10.1084/jem.20091097

Cite This Page:

Rockefeller University Press. "Targeting cancerous vessels." ScienceDaily. ScienceDaily, 10 January 2010. <www.sciencedaily.com/releases/2010/01/100104091128.htm>.
Rockefeller University Press. (2010, January 10). Targeting cancerous vessels. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2010/01/100104091128.htm
Rockefeller University Press. "Targeting cancerous vessels." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104091128.htm (accessed November 29, 2014).

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