Featured Research

from universities, journals, and other organizations

Nlp: all new tumor-forming protein

Date:
January 24, 2010
Source:
Journal of Clinical Investigation
Summary:
Proteins that when expressed out of context cause a cell to become cancerous are known as oncogenic proteins. Researchers have now identified in mice a new oncogenic protein that is also expressed at elevated levels in human breast cancers and lung carcinomas.

Proteins that when expressed out of context cause a cell to become cancerous are known as oncogenic proteins. Qimin Zhan and colleagues, at the Chinese Academy of Medical Sciences and Peking Union Medical College, People's Republic of China, have now identified in mice a new oncogenic protein that is also expressed at elevated levels in human breast cancers and lung carcinomas.

In the study, Nlp was found to be expressed at elevated levels in the majority of human breast and lung cancers analyzed. In the lung cancers analyzed, these high protein levels were a result of NLP gene amplification. In vitro analysis of the function of Nlp indicated that it conferred on cells tumorigenic properties, suggesting that it was an oncogenic protein. Consistent with this, mice engineered to overexpress Nlp spontaneously developed tumorigenesis in the breast, ovary, and testicle.

The authors therefore suggest that Nlp abnormalities might lead to tumor formation and development.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shujuan Shao, Rong Liu, Yang Wang, Yongmei Song, Lihui Zuo, Liyan Xue, Ning Lu, Ning Hou, Mingrong Wang, Xiao Yang and Qimin Zhan. Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39447

Cite This Page:

Journal of Clinical Investigation. "Nlp: all new tumor-forming protein." ScienceDaily. ScienceDaily, 24 January 2010. <www.sciencedaily.com/releases/2010/01/100119224924.htm>.
Journal of Clinical Investigation. (2010, January 24). Nlp: all new tumor-forming protein. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/01/100119224924.htm
Journal of Clinical Investigation. "Nlp: all new tumor-forming protein." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119224924.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins