Featured Research

from universities, journals, and other organizations

Genetic mutations associated with suicide risk among patients with depression

Date:
February 2, 2010
Source:
JAMA and Archives Journals
Summary:
Single mutations in genes involved with nerve cell formation and growth appear to be associated with the risk of attempting suicide among individuals with depression, according to a report posted online today that will appear in the April print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Single mutations in genes involved with nerve cell formation and growth appear to be associated with the risk of attempting suicide among individuals with depression, according to a report posted online that will appear in the April print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Related Articles


An estimated 10 to 20 million suicides are attempted each year around the world, and 1 million are completed, according to background information in the article. Patients with psychiatric disorders are more likely to attempt suicide, and those with depression or other mood disorders are at higher risk. "Twin and family studies suggest that suicide and suicide attempts are heritable traits and likely part of the same phenotype, with completed suicide and suicide attempts clustering in the same families," the authors write. "The genetic risk factors for suicide appear to be independent from the underlying psychiatric disorder."

Martin A. Kohli, Ph.D., then of the Max Planck Institute of Psychiatry, Munich, Germany, and now of the John P. Hussman Institute for Human Genomics, Miami, and colleagues investigated genetic variants among 394 depressed patients, including 113 who had attempted suicide, and 366 matched healthy control participants. The authors then replicated their results in 744 German patients with major depressive disorder (152 of whom had attempted suicide) and 921 African American non-psychiatric clinic patients (119 of whom had attempted suicide).

The researchers investigated single-nucleotide polymorphisms (SNPs, or variants in a single base pair along a strand of DNA) in two genes associated with the neurotrophic system (which produces proteins involved in nerve cell growth). Five SNPs appeared significantly more common among individuals with a history of suicide attempts. Carriers of the three most significant markers had a 4.5-fold higher risk of attempting suicide than those who carried none of the three mutations.

"The facts that the genetic associations with suicide attempts were stronger when comparing depressed patients with suicide attempts vs. depressed patients without suicide attempts than with healthy control subjects and that these SNPs were not associated with major depressive disorder suggest that these associations are specific to suicide attempts" and not linked to depression in general, the authors write.

"This supports the large body of evidence that dysfunctional neurotrophic signaling might be involved in the pathophysiology of suicidal behavior," they conclude.

Editor's Note: This study is supported by a grant from the Exzellenz-Stiftung of the Max Planck Society and by a grant from the National Genome Research Network, Federal Ministry of Education and Research.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Martin A. Kohli; Daria Salyakina; Andrea Pfennig; Susanne Lucae; Sonja Horstmann; Andreas Menke; Stefan Kloiber; Johannes Hennings; Bekh B. Bradley; Kerry J. Ressler; Manfred Uhr; Bertram Muller-Myhsok; Florian Holsboer; Elisabeth B. Binder. Association of Genetic Variants in the Neurotrophic Receptor-Encoding Gene NTRK2 and a Lifetime History of Suicide Attempts in Depressed Patients. Arch Gen Psychiatry, 2010 [link]

Cite This Page:

JAMA and Archives Journals. "Genetic mutations associated with suicide risk among patients with depression." ScienceDaily. ScienceDaily, 2 February 2010. <www.sciencedaily.com/releases/2010/02/100201171527.htm>.
JAMA and Archives Journals. (2010, February 2). Genetic mutations associated with suicide risk among patients with depression. ScienceDaily. Retrieved April 2, 2015 from www.sciencedaily.com/releases/2010/02/100201171527.htm
JAMA and Archives Journals. "Genetic mutations associated with suicide risk among patients with depression." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201171527.htm (accessed April 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, April 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins