Featured Research

from universities, journals, and other organizations

Genetic mutations associated with suicide risk among patients with depression

Date:
February 2, 2010
Source:
JAMA and Archives Journals
Summary:
Single mutations in genes involved with nerve cell formation and growth appear to be associated with the risk of attempting suicide among individuals with depression, according to a report posted online today that will appear in the April print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Single mutations in genes involved with nerve cell formation and growth appear to be associated with the risk of attempting suicide among individuals with depression, according to a report posted online that will appear in the April print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

An estimated 10 to 20 million suicides are attempted each year around the world, and 1 million are completed, according to background information in the article. Patients with psychiatric disorders are more likely to attempt suicide, and those with depression or other mood disorders are at higher risk. "Twin and family studies suggest that suicide and suicide attempts are heritable traits and likely part of the same phenotype, with completed suicide and suicide attempts clustering in the same families," the authors write. "The genetic risk factors for suicide appear to be independent from the underlying psychiatric disorder."

Martin A. Kohli, Ph.D., then of the Max Planck Institute of Psychiatry, Munich, Germany, and now of the John P. Hussman Institute for Human Genomics, Miami, and colleagues investigated genetic variants among 394 depressed patients, including 113 who had attempted suicide, and 366 matched healthy control participants. The authors then replicated their results in 744 German patients with major depressive disorder (152 of whom had attempted suicide) and 921 African American non-psychiatric clinic patients (119 of whom had attempted suicide).

The researchers investigated single-nucleotide polymorphisms (SNPs, or variants in a single base pair along a strand of DNA) in two genes associated with the neurotrophic system (which produces proteins involved in nerve cell growth). Five SNPs appeared significantly more common among individuals with a history of suicide attempts. Carriers of the three most significant markers had a 4.5-fold higher risk of attempting suicide than those who carried none of the three mutations.

"The facts that the genetic associations with suicide attempts were stronger when comparing depressed patients with suicide attempts vs. depressed patients without suicide attempts than with healthy control subjects and that these SNPs were not associated with major depressive disorder suggest that these associations are specific to suicide attempts" and not linked to depression in general, the authors write.

"This supports the large body of evidence that dysfunctional neurotrophic signaling might be involved in the pathophysiology of suicidal behavior," they conclude.

Editor's Note: This study is supported by a grant from the Exzellenz-Stiftung of the Max Planck Society and by a grant from the National Genome Research Network, Federal Ministry of Education and Research.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Martin A. Kohli; Daria Salyakina; Andrea Pfennig; Susanne Lucae; Sonja Horstmann; Andreas Menke; Stefan Kloiber; Johannes Hennings; Bekh B. Bradley; Kerry J. Ressler; Manfred Uhr; Bertram Muller-Myhsok; Florian Holsboer; Elisabeth B. Binder. Association of Genetic Variants in the Neurotrophic Receptor-Encoding Gene NTRK2 and a Lifetime History of Suicide Attempts in Depressed Patients. Arch Gen Psychiatry, 2010 [link]

Cite This Page:

JAMA and Archives Journals. "Genetic mutations associated with suicide risk among patients with depression." ScienceDaily. ScienceDaily, 2 February 2010. <www.sciencedaily.com/releases/2010/02/100201171527.htm>.
JAMA and Archives Journals. (2010, February 2). Genetic mutations associated with suicide risk among patients with depression. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2010/02/100201171527.htm
JAMA and Archives Journals. "Genetic mutations associated with suicide risk among patients with depression." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201171527.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins