Featured Research

from universities, journals, and other organizations

World's first in-depth study of the malaria parasite genome

Date:
February 6, 2010
Source:
Nanyang Technological University
Summary:
Groundbreaking research could lead to the development of more potent drugs or a vaccine for malaria. Scientists have scored a world first in successfully using transcriptional profiling to uncover hitherto unknown gene expression (activity) patterns in malaria.

Groundbreaking research done at Singapore's Nanyang Technological University's (NTU) School of Biological Sciences (SBS) could lead to the development of more potent drugs or a vaccine for malaria, which is transmitted to humans by infected mosquitoes and kills up to three million people each year.

Related Articles


Assistant Professor Zbynek Bozdech and his team of researchers, including graduate students and post-doctorals from SBS' Division of Genomics & Genetics, have scored a world first in successfully using transcriptional profiling to uncover hitherto unknown gene expression (activity) patterns in malaria.

The research team's breakthrough made the January 2010 edition of Nature Biotechnology, which is a satellite publication of Nature.

Transcriptional profiling is the measurement of the activity of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment.

This outcome in infectious disease pathology could potentially be the decade's big breakthrough as it has yielded critical information about how the malaria parasite Plasmodium falciparum -- the most deadly form of malaria -- responds to existing compounds with curative potential.

The genome or the complete DNA content of the Plasmodium falciparum has about 5,300 genes. Up till now, scientists have a good understanding of the gene functions for only about half of the more than 5,000 genes. Using transcriptional profiling, Asst Prof Zbynek Bozdech's team has successfully uncovered the gene functions for almost the entire genome, with more than 90 percent of the gene functions from the previously unknown half now better understood.

"Drawing on our findings, pharmaceutical companies could explore ways to design a drug that targets the weakest link," said Asst Prof Bozdech of his research which was supported with S$900,000 in grants from Singapore's Ministry of Education and the National Medical Research Council. "We have predicted all the genes that could be used for a vaccine as well," he said.

Researchers at Germany's Bernhard Nocht Institute for Tropical Medicine, have validated the research findings, which are expected to provide exciting new insights into parasite biology.

"The successful NTU-BNI joint project has led to the creation of the world's first database to predict the functions of more than 2,500 genes of the malaria parasite previously unknown. The database would be useful to scientists around the world who are developing new vaccines and drugs," says Dr. Tim Gilberger, Head, Malaria Research at BNI.

Preventing malaria infection is important because resistance to anti-malarial drugs is a growing problem worldwide. There is currently no vaccine for malaria, which is widespread in poorer countries where it remains a hindrance to economic development. Also of growing concern to scientists is the confirmation of the first signs of resistance to the only affordable treatment left in the global medicine cabinet for malaria: Artemisinin.

In successfully using transcriptional profiling to study the behavior of the malaria parasite, NTU's researchers have ventured into the unknown and paved the way for future breakthroughs in healthcare.


Story Source:

The above story is based on materials provided by Nanyang Technological University. Note: Materials may be edited for content and length.


Cite This Page:

Nanyang Technological University. "World's first in-depth study of the malaria parasite genome." ScienceDaily. ScienceDaily, 6 February 2010. <www.sciencedaily.com/releases/2010/02/100205102607.htm>.
Nanyang Technological University. (2010, February 6). World's first in-depth study of the malaria parasite genome. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2010/02/100205102607.htm
Nanyang Technological University. "World's first in-depth study of the malaria parasite genome." ScienceDaily. www.sciencedaily.com/releases/2010/02/100205102607.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins