Featured Research

from universities, journals, and other organizations

Immune system turns on the body in narcolepsy

Date:
February 17, 2010
Source:
Journal of Clinical Investigation
Summary:
It is thought that the sleep disorder narcolepsy is an autoimmune disorder -- that is, it is caused by the individual's immune system attacking certain cells in the body -- but this had not been proven definitively. But now, researchers have now identified autoantibodies (immune molecules that target a natural protein in the body rather than a protein from an infectious agent) in narcolepsy patients.

It is thought that the sleep disorder narcolepsy is an autoimmune disorder -- that is, it is caused by the individual's immune system attacking certain cells in the body -- but this had not been proven definitively. But now, researchers have now identified autoantibodies (immune molecules that target a natural protein in the body rather than a protein from an infectious agent) in narcolepsy patients.

Individuals with the sleep disorder narcolepsy suffer with excessive daytime sleepiness and attacks of muscle paralysis triggered by strong emotions (a condition known as cataplexy). It is thought that narcolepsy is an autoimmune disorder -- that is, it is caused by the individual's immune system attacking certain cells in the body -- but this has not yet been proven definitively.

However, Mehdi Tafti and colleagues, at the University of Lausanne, Switzerland, have now identified autoantibodies (immune molecules that target a natural protein in the body rather than a protein from an infectious agent) that target the natural protein Trib2 in narcolepsy patients with cataplexy, suggesting that narcolepsy is indeed an autoimmune disorder.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vesna Cvetkovic-Lopes, Laurence Bayer, Stéphane Dorsaz, Stéphanie Maret, Sylvain Pradervand, Yves Dauvilliers, Michel Lecendreux, Gert-Jan Lammers, Claire E.h.m. Donjacour, Renaud A. Du Pasquier, Corinne Pfister, Brice Petit, Hyun Hor, Michel Mühlethaler and Mehdi Tafti. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest., DOI: 10.1172/JCI41366

Cite This Page:

Journal of Clinical Investigation. "Immune system turns on the body in narcolepsy." ScienceDaily. ScienceDaily, 17 February 2010. <www.sciencedaily.com/releases/2010/02/100215173947.htm>.
Journal of Clinical Investigation. (2010, February 17). Immune system turns on the body in narcolepsy. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/02/100215173947.htm
Journal of Clinical Investigation. "Immune system turns on the body in narcolepsy." ScienceDaily. www.sciencedaily.com/releases/2010/02/100215173947.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins