Featured Research

from universities, journals, and other organizations

New study casts doubt on link between chronic fatigue syndrome and human retrovirus XMRV

Date:
February 26, 2010
Source:
BMJ-British Medical Journal
Summary:
A new study casts doubt on recent claims that a human retrovirus known as XMRV is linked to chronic fatigue syndrome or ME (myalgic encephalitis).

A new study published on the British Medical Journal website casts doubt on recent claims that a human retrovirus known as XMRV is linked to chronic fatigue syndrome or ME (myalgic encephalitis).

This is the third study to refute the original US study reporting the link.

Chronic fatigue syndrome is a debilitating condition that affects millions of people worldwide with disabling physical and mental fatigue that does not improve with rest. Its causes remain unclear, but many people say their illness started after a viral infection.

A recent study from the United States detected XMRV in two thirds of patients with chronic fatigue syndrome, but could not conclusively prove a direct (causal) link between the virus and the disease.

In January 2010, another research team found no evidence of XMRV in 186 patients with chronic fatigue syndrome in the United Kingdom. A third study, published earlier this month, also failed to identify XMRV in 170 patients.

So a team from the Netherlands, led by Professors Frank van Kuppeveld and Jos van der Meer, investigated whether this link could be confirmed in an independent European group of patients with chronic fatigue syndrome.

They examined the DNA from XMRV in the blood cells of 32 Dutch patients with chronic fatigue syndrome and 43 healthy controls, matched by age, sex and geographical area. Two highly sensitive tests were performed on two different target genes.

They found no evidence of XMRV in any of the patients or the controls, adding to the negative evidence in the two previous studies.

"Although our patient group was relatively small and we cannot formally rule out a role of XMRV, our data cast doubt on the claim that this virus is associated with chronic fatigue syndrome in the majority of patients," say the authors.

One reason why these results contradict the original findings may be that the US study involved patients from a specific outbreak of chronic fatigue syndrome in the mid-80s that has already been linked to several viruses, explain the authors. It is possible that XMRV is implicated in this outbreak, but does not play a substantial role in most cases of chronic fatigue syndrome elsewhere, they conclude.

To reconcile these different findings, other US laboratories are currently investigating XMRV and chronic fatigue syndrome, and the results are eagerly awaited, say researchers from Imperial College London and King's College London in an accompanying editorial.

"If the link fails to hold up, it will be another bitter disappointment to affected patients. Nonetheless, the current debate will still bring critical attention to the causes of chronic fatigue syndrome, and XMRV may turn out to be important in the pathogenesis of other diseases," they conclude.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "New study casts doubt on link between chronic fatigue syndrome and human retrovirus XMRV." ScienceDaily. ScienceDaily, 26 February 2010. <www.sciencedaily.com/releases/2010/02/100225214803.htm>.
BMJ-British Medical Journal. (2010, February 26). New study casts doubt on link between chronic fatigue syndrome and human retrovirus XMRV. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2010/02/100225214803.htm
BMJ-British Medical Journal. "New study casts doubt on link between chronic fatigue syndrome and human retrovirus XMRV." ScienceDaily. www.sciencedaily.com/releases/2010/02/100225214803.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins