Featured Research

from universities, journals, and other organizations

Clinical trial participation alone may not be associated with improved outcomes for childhood cancer patients

Date:
March 1, 2010
Source:
JAMA and Archives Journals
Summary:
Children with the most common childhood cancer did not experience improved outcomes from participating in a clinical trial between 1997 and 2005. Researchers studied 322 patients with newly diagnosed acute lymphoblastic leukemia (a cancer involving the white blood cells), approximately half of whom participated in one of several available clinical trial protocols for the disease.

Children with the most common childhood cancer did not experience improved outcomes from participating in a clinical trial between 1997 and 2005.

Carl Koschmann, M.D., and colleagues at the University of Washington and Seattle Children's Hospital studied 322 patients with newly diagnosed acute lymphoblastic leukemia (a cancer involving the white blood cells), approximately half of whom participated in one of several available clinical trial protocols for the disease.

Overall, 79 percent of the patients survived five years without recurrence of their leukemia, with no significant difference between study participants and non-participants (80 percent vs. 77 percent). "Clinical trial participation does not, by itself, lead to improved outcome for pediatric patients with acute lymphoblastic leukemia in the current era," the authors conclude. "Discussions about participation in a clinical trial should focus on improvement of future therapy, not the direct benefit of the research participant."

"Considerable evidence indicates that clinical trials are associated with substantial benefits as measured by both public health and economic gains," writes Steven Joffe, M.D., M.P.H., of the Dana-Farber Cancer Institute, Boston, in an accompanying editorial. "In the modern era, five-year survival rates for children with acute lymphoblastic leukemia are 80 percent to 90 percent. It is likely that these remarkable outcomes owe much not only to the legacy of treatment insights derived from past trials, but also to the happy side effect of improved quality attributable to the existence of a cooperative clinical trials program and infrastructure in the settings in which most children with cancer receive their care."

The research appears in Archives of Pediatrics & Adolescent Medicine.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal References:

  1. Carl Koschmann; Blythe Thomson; Douglas S. Hawkins. No Evidence of a Trial Effect in Newly Diagnosed Pediatric Acute Lymphoblastic Leukemia. Arch Pediatr Adolesc Med, 2010; 164 (3): 214-217 [link]
  2. Steven Joffe. Framing the Benefits of Cancer Clinical Trials. Arch Pediatr Adolesc Med, 2010; 164 (3): 293-294 [link]

Cite This Page:

JAMA and Archives Journals. "Clinical trial participation alone may not be associated with improved outcomes for childhood cancer patients." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/03/100301171056.htm>.
JAMA and Archives Journals. (2010, March 1). Clinical trial participation alone may not be associated with improved outcomes for childhood cancer patients. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/03/100301171056.htm
JAMA and Archives Journals. "Clinical trial participation alone may not be associated with improved outcomes for childhood cancer patients." ScienceDaily. www.sciencedaily.com/releases/2010/03/100301171056.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins