Featured Research

from universities, journals, and other organizations

Downstream processes of ion channel inactivation revealed

Date:
March 2, 2010
Source:
Rockefeller University Press
Summary:
Researchers have revealed new details of the mechanisms of ion channel inactivation.

Two studies by researchers at The Johns Hopkins University School of Medicine reveal new details of the mechanisms of ion channel inactivation. The papers appear in the March issue of The Journal of General Physiology.

Related Articles


After opening, many ion channels spontaneously close by inactivation, a process distinct from that involved in opening. The inactivation of channels is important for a variety of biological processes, including the timing of action potentials and the control of calcium permeability, which affects many aspects of intracellular signaling. Although the events of Ca2+-dependent inactivation (CDI) and voltage-dependent inactivation (VDI) have been unveiled in the past decade, the downstream mechanisms remained unclear.

Tadross et al. studied both CDI and VDI in Cav1.3 channels and showed them to differ not only in their initiation mechanisms but also in their distinct molecular endpoints. For CDI, a clear pattern emerges: activation-enhancing mutations proportionately weaken inactivation, supporting the idea that CDI reduces channel permeability by allosteric hindrance of the activation gate. For VDI, the data implicate a "hinged lid-shield" mechanism, similar to a hinged-lid process, with a previously unrecognized feature, a "shield" in Cav1.3 channels that is specialized to repel lid closure.

In a Commentary accompanying the papers, Jianmin Cui (Washington University, St. Louis) examines the mechanisms of inactivation and provides context for the importance of the new findings by Tadross et al.

Cui, J. 2010. J. Gen. Physiol. doi:10.1085/jgp.201010421. Tadross, M.R., et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910308. Tadross, M.R., and D.T. Yue. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910309.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "Downstream processes of ion channel inactivation revealed." ScienceDaily. ScienceDaily, 2 March 2010. <www.sciencedaily.com/releases/2010/03/100302162301.htm>.
Rockefeller University Press. (2010, March 2). Downstream processes of ion channel inactivation revealed. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/03/100302162301.htm
Rockefeller University Press. "Downstream processes of ion channel inactivation revealed." ScienceDaily. www.sciencedaily.com/releases/2010/03/100302162301.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins