Featured Research

from universities, journals, and other organizations

'Flying vaccinator': Can genetically engineered mosquitoes provide a new strategy against malaria?

Date:
March 19, 2010
Source:
Wiley-Blackwell
Summary:
Mosquitoes transmit infectious diseases to millions of people every year, including malaria for which there is no effective vaccine. New research reveals that mosquito genetic engineering may turn the transmitter into a natural "flying vaccinator," providing a new strategy for biological control over the disease.

Mosquitoes transmit infectious diseases to millions of people every year, including malaria for which there is no effective vaccine. New research published in Insect Molecular Biology reveals that mosquito genetic engineering may turn the transmitter into a natural 'flying vaccinator', providing a new strategy for biological control over the disease.

Related Articles


The research, led by Associate Professor Shigeto Yoshida from the Jichi Medical University in Japan, targets the saliva gland of the Anopheles stephensi mosquitoes, the main vectors of human malaria.

"Blood-sucking arthropods including mosquitoes, sand flies and ticks transmit numerous infectious agents during blood feeding," said Yoshida. "This includes malaria, which kills between 1-2 million people, mostly African children, a year. The lack of an effective vaccine means control of the carrier has become a crucial objective to combating the disease."

For the past decade it has been theorized that genetic engineering of the mosquito could create a 'flying vaccinator,' raising hopes for their use as a new strategy for malaria control. However so far research has been limited to a study of the insect's gut and the 'flying vaccinator' theory was not developed.

"Following bites, protective immune responses are induced, just like a conventional vaccination but with no pain and no cost," said Yoshida. "What's more continuous exposure to bites will maintain high levels of protective immunity, through natural boosting, for a life time. So the insect shifts from being a pest to being beneficial."

In this study Dr. Yoshida's team successfully generated a transgenic mosquito expressing the Leishmania vaccine within its saliva. Bites from the insect succeeded in raising antibodies, indicating successful immunization with the Leishmania vaccine through blood feeding.

While 'flying vaccinator' theory may now be scientifically possible the question of ethics hangs over the application of the research. A natural and uncontrolled method of delivering vaccines, without dealing with dosage and consent, alongside public acceptance to the release of 'vaccinating' mosquitoes, provide barriers to this method of disease control.

"For the past decade it has been postulated that the salivary gland could be the way to gain biological control over this important infectious disease," concluded Yoshida. "In this study we have shown, for the first time, the achievement of the original concept of the 'flying vaccinator."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "'Flying vaccinator': Can genetically engineered mosquitoes provide a new strategy against malaria?." ScienceDaily. ScienceDaily, 19 March 2010. <www.sciencedaily.com/releases/2010/03/100318192658.htm>.
Wiley-Blackwell. (2010, March 19). 'Flying vaccinator': Can genetically engineered mosquitoes provide a new strategy against malaria?. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/03/100318192658.htm
Wiley-Blackwell. "'Flying vaccinator': Can genetically engineered mosquitoes provide a new strategy against malaria?." ScienceDaily. www.sciencedaily.com/releases/2010/03/100318192658.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins