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New form of insulin can be inhaled rather than injected

Date:
March 24, 2010
Source:
American Chemical Society
Summary:
A new inhalable powder carrying insulin not only eliminates the pain of injections, but actually delivers the medication faster than a needle, researchers.

This new, quick acting insulin inhaler uses a powder (AFREZZA™) to deliver the medication.
Credit: The MannKind Corporation

Scientists have described a new ultra-rapid acting mealtime insulin (AFREZZA™) that is orally inhaled for absorption via the lung. Because the insulin is absorbed so rapidly, AFREZZA's profile closely mimics the normal early insulin response seen in healthy individuals. AFREZZA is awaiting approval by the U. S. Food and Drug Administration (FDA). This presentation took place at the 239th American Chemical Society National Meeting, being held in San Francisco, California, USA March 21-25.

Andrea Leone-Bay, Ph.D. and colleagues at MannKind Corporation said that the new insulin product, uses the Technosphere® technology, a delivery technology that is applicable to a wide variety of other drugs that are currently injected. Like insulin, these medications are proteins that would be digested and destroyed in the stomach if taken by mouth.

One such product, MKC-180, is a Technosphere® formulation of a natural hormone that controls appetite and is under investigation as a therapy for obesity using pulmonary delivery. "In nonclinical studies remarkable reductions in food intake have been observed," Leone-Bay said. MannKind is also evaluating Technosphere® technology with drugs that treat pain and osteoporosis.

"Our proprietary Technosphere® Technology platform is based on particles formed by the self-assembly of a small molecule," Leone-Bay explained. "Drugs can be loaded onto these particles, which are then dried to form a dry powder. Using a thumb-sized device, patients inhale a small amount of the powder, roughly equivalent to a pinch of salt. This powder dissolves immediately after inhalation and the drug is absorbed into the patient's bloodstream. Most importantly, the drug is absorbed ultra-rapidly so it becomes effective much more quickly than an injection of the same drug. For some drugs, ultra-rapid systemic delivery provides distinct clinical advantages over injection, including profiles that match the body's natural responses in processes like hormone secretion."

AFREZZA™ (insulin human rDNA origin) Inhalation Powder is an ultra-rapid acting insulin intended for use at mealtime to control the rapid rise in blood sugar levels that occurs in people with diabetes immediately after a meal. At other times, people with diabetes would take injections of other kinds of insulin.

Leone-Bay said AFREZZA™ controls glucose as well as current state-of-the-art treatments, poses a lower risk of hypoglycemia than that typically associated with mealtime insulin therapy, and leads to less weight gain compared to other insulin treatments," according to Leone-Bay. "Additionally, and importantly, AFREZZA™ provides the unique benefit of a small, discreet, and easier-to-use inhalation device."


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "New form of insulin can be inhaled rather than injected." ScienceDaily. ScienceDaily, 24 March 2010. <www.sciencedaily.com/releases/2010/03/100323133041.htm>.
American Chemical Society. (2010, March 24). New form of insulin can be inhaled rather than injected. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/03/100323133041.htm
American Chemical Society. "New form of insulin can be inhaled rather than injected." ScienceDaily. www.sciencedaily.com/releases/2010/03/100323133041.htm (accessed October 23, 2014).

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