Featured Research

from universities, journals, and other organizations

Too much insulin a bad thing for the heart?

Date:
April 21, 2010
Source:
Journal of Clinical Investigation
Summary:
A team of researchers in Japan has generated data in mice that suggest that using insulin to treat diabetes could be harmful if the patient has chronic high blood pressure.

A team of researchers at Chiba University Graduate School of Medicine, Japan, has generated data in mice that suggest that using insulin to treat diabetes could be harmful if the patient has chronic high blood pressure.

Insulin is a hormone that controls the levels of glucose, a key source of energy, in our blood via its effects on the liver, muscle, and fat cells. How insulin affects the heart is not very clear, animal studies suggest that insulin protects the heart from stresses, whereas clinical studies suggest a link between high levels of insulin in the blood and heart failure.

The team, led by Issei Komuro, has generated data in mice indicating that while persistent high blood pressure induces liver cell resistance to insulin, it enhances insulin signaling in the heart. This excessive chronic insulin signaling exacerbated heart failure caused by high blood pressure. Importantly, although treating type 1 diabetic mice, which produce no insulin, with insulin stabilized their levels of glucose in the blood, it increased heart failure.

Together, these data lead the authors to suggest that insulin treatment could be harmful in the setting of chronic high blood pressure and that maintaining insulin signaling at normal levels is crucial for treating heart failure.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ippei Shimizu, Tohru Minamino, Haruhiro Toko, Sho Okada, Hiroyuki Ikeda, Noritaka Yasuda, Kaoru Tateno, Junji Moriya, Masataka Yokoyama, Aika Nojima, Gou Young Koh, Hiroshi Akazawa, Ichiro Shiojima, C. Ronald Kahn, E. Dale Abel and Issei Komuro. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40096

Cite This Page:

Journal of Clinical Investigation. "Too much insulin a bad thing for the heart?." ScienceDaily. ScienceDaily, 21 April 2010. <www.sciencedaily.com/releases/2010/04/100419233109.htm>.
Journal of Clinical Investigation. (2010, April 21). Too much insulin a bad thing for the heart?. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2010/04/100419233109.htm
Journal of Clinical Investigation. "Too much insulin a bad thing for the heart?." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419233109.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins