Featured Research

from universities, journals, and other organizations

Fighting fungal infections with bacteria

Date:
May 2, 2010
Source:
Society for General Microbiology
Summary:
A bacterial pathogen can communicate with yeast to block the development of drug-resistant yeast infections, say scientists. The research could be a step towards new strategies to prevent hospital-acquired infections associated with medical implants.

A bacterial pathogen can communicate with yeast to block the development of drug-resistant yeast infections, say Irish scientists writing in the May issue of Microbiology. The research could be a step towards new strategies to prevent hospital-acquired infections associated with medical implants.

Researchers from University College Cork in Ireland studied the interaction between the bacterium Pseudomonas aeruginosa, which is often associated with severe burns, and the yeast Candida albicans, which can grow on plastic surfaces such as catheters. Both microbes are very common and although they are normally harmless to healthy individuals, they can cause disease in immunocompromised people.

The team discovered that molecules produced by P. aeruginosa bacteria were able to hinder the development of C. albicans 'biofilms' on silicone, when the yeast cells clump together on the surface of the plastic. Interestingly, the interaction between the two organisms did not depend on the well-studied bacterial communication system called Quorum Sensing, indicating that a novel signalling mechanism was at play.

C. albicans is the most common hospital-acquired fungal infection and can cause illness by sticking to and colonising plastic surfaces implanted in the body such as catheters, cardiac devices or prosthetic joints. This biofilm formation is a key aspect of C. albicans infection and is problematic as biofilms are often resistant to the antibiotics used to treat them. Dr John Morrissey, who led the team of researchers, said, "Candida albicans can cause very serious deep infections in susceptible patients and it is often found in biofilm form. It is therefore important to understand the biofilm process and how it might be controlled."

Dr Morrissey believes his work may lead to significant clinical benefits. "If we can exploit the same inhibitory strategy that the bacterium P. aeruginosa uses, then we might be able to design drugs that can be used as antimicrobials to disperse yeast biofilms after they form, or as additives onto plastics to prevent biofilm formation on medical implants," he said. "The next steps are to identify the chemical that the bacterium produces and to find out what its target in the yeast is. We can then see whether this will be a feasible lead for the development of new drugs for clinical application."


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "Fighting fungal infections with bacteria." ScienceDaily. ScienceDaily, 2 May 2010. <www.sciencedaily.com/releases/2010/05/100501013525.htm>.
Society for General Microbiology. (2010, May 2). Fighting fungal infections with bacteria. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/05/100501013525.htm
Society for General Microbiology. "Fighting fungal infections with bacteria." ScienceDaily. www.sciencedaily.com/releases/2010/05/100501013525.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins