Featured Research

from universities, journals, and other organizations

Cholesterol drugs may help improve hip replacement outcomes

Date:
May 5, 2010
Source:
American Academy of Orthopaedic Surgeons
Summary:
The use of statins -- drugs commonly prescribed to help lower cholesterol levels -- may play an important role in decreasing complications among patients undergoing total hip replacement, according to a new study.

The use of statins -- drugs commonly prescribed to help lower cholesterol levels -- may play an important role in decreasing complications among patients undergoing total hip replacement (THR), according to a study published in the May 2010 issue of The Journal of Bone and Joint Surgery (JBJS).

Related Articles


"We found that use of statins substantially reduced the risk of revision after hip replacement surgery, indicating that the biological effects of statins may play a role in the sustainability of hip implants," said Theis Thillemann, MD, fellow in the department of orthopaedic surgery, Aarhus University Hospital, Denmark.

Using records from the Danish Hip Arthroplasty Registry, a national database of patients who had hip replacement, Dr. Thillemann and his colleagues evaluated the effect of statin use on the need for revision surgery and found that patients who were taking statins for cholesterol control postoperatively had a significantly lower risk of revision during the 10-year period following THR. In addition, the researchers noted the risk of revision decreased with longer use of the statins.

"In hip replacement surgery, nearly 80 percent of patients are older than 60 years," he noted. "As a result, many of these patients have chronic medical diseases for which they are taking medicine. Although it's recognized that many of these drugs affect bone metabolism, currently there is limited information on the implications of other medical treatments on implant survival after THR."

"The survival of a hip implant is related to many different mechanisms," Dr. Thillemann noted. "Statins have been associated with improved bone metabolism, improved anti-inflammatory effects and improved prognosis after infections," added Dr. Thillemann.

Because statins are so widely used in older individuals, the same population that is most likely to undergo total hip replacement, Dr. Thillemann said studying the effects of the drugs on THR patients was a logical step.

Dr. Thillemann noted that these drugs may help to improve THR outcomes in several ways, including to:

  • encourage bone formation, which may improve the fixation of the implant to the bone;
  • reduce inflammation, which can cause the implant to become loose
  • reduce the rate of infections at the site of the implant.

While this study evaluated the post-operative use of statins in patients who were taking the drugs primarily for a cardiovascular condition, Dr. Thillemann said future research will help determine whether statins should be prescribed prior to THR in otherwise healthy patients, as well as to determine optimum dosing regimens.

Dr. Thillemann added, any general recommendation of statin use in THR patients depends on several factors, including the:

  • association between statin use and the risk of revision;
  • effect and safety of statin therapy on other existing medical conditions
  • price of statin therapy.

"For the clinician, it is important to know that statins may improve longevity of hip replacements," Dr. Thillemann noted. "In our research group, we continue to our look into the role of statins in the prognosis of hip implants, both in clinical and experimental study designs. Ideally, further studies will confirm our results and make it possible to recommend statin therapy to all patients undergoing hip replacement surgery."


Story Source:

The above story is based on materials provided by American Academy of Orthopaedic Surgeons. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thillemann et al. The Risk of Revision After Primary Total Hip Arthroplasty Among Statin Users: A Nationwide Population-Based Nested Case-Control Study. The Journal of Bone and Joint Surgery, 2010; 92 (5): 1063 DOI: 10.2106/JBJS.H.01805

Cite This Page:

American Academy of Orthopaedic Surgeons. "Cholesterol drugs may help improve hip replacement outcomes." ScienceDaily. ScienceDaily, 5 May 2010. <www.sciencedaily.com/releases/2010/05/100503111758.htm>.
American Academy of Orthopaedic Surgeons. (2010, May 5). Cholesterol drugs may help improve hip replacement outcomes. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2010/05/100503111758.htm
American Academy of Orthopaedic Surgeons. "Cholesterol drugs may help improve hip replacement outcomes." ScienceDaily. www.sciencedaily.com/releases/2010/05/100503111758.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins