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Conquering a severe complication of celiac disease

Date:
May 3, 2010
Source:
Journal of Clinical Investigation
Summary:
One severe complication of celiac disease is enteropathy-associated T cell lymphoma, an invasive lymphoma with poor prognosis. New research has identified the anti-death signals transmitted to immune cells in the wall of the small intestine by the soluble factor IL-15 that contribute to the development of enteropathy-associated T cell lymphoma, providing potential new targets for treating type II refractory celiac disease -- an intermediary clinical state between celiac disease and enteropathy-associated T cell lymphoma.

One severe complication of celiac disease is enteropathy-associated T cell lymphoma, a high-grade invasive lymphoma with a very poor prognosis. Previous research has suggested that chronic exposure of immune cells in the walls of the small intestine, which are known as intraepithelial lymphocytes, to potent anti-death signals initiated by the soluble factor IL-15 contributes to the development of enteropathy-associated T cell lymphoma.

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A team of researchers, at INSERM U989, Université René Descartes, France, has now identified the survival signals delivered by IL-15 to freshly isolated human intraepithelial lymphocytes and to intraepithelial lymphocyte cell lines derived from patients with type II refractory celiac disease -- a clinical state considered an intermediary step between celiac disease and enteropathy-associated T cell lymphoma. Importantly, treatment with an antibody directed at IL-15 caused intraepithelial lymphocytes to die and wiped out their accumulation in mice overexpressing human IL-15 in the lining of their gut.

The team, led by Nadine Cerf-Bensussan and Bertrand Meresse, therefore suggests that IL-15 and its downstream survival signals might provide new targets for the treatment of type II refractory celiac disease.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Malamut et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI41344

Cite This Page:

Journal of Clinical Investigation. "Conquering a severe complication of celiac disease." ScienceDaily. ScienceDaily, 3 May 2010. <www.sciencedaily.com/releases/2010/05/100503174020.htm>.
Journal of Clinical Investigation. (2010, May 3). Conquering a severe complication of celiac disease. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2010/05/100503174020.htm
Journal of Clinical Investigation. "Conquering a severe complication of celiac disease." ScienceDaily. www.sciencedaily.com/releases/2010/05/100503174020.htm (accessed March 28, 2015).

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