Featured Research

from universities, journals, and other organizations

Vaccination reduces burden of childhood rotavirus disease

Date:
May 13, 2010
Source:
Wiley-Blackwell
Summary:
Vaccination of infants with Rotarix or RotaTeq significantly reduces the rate of severe rotavirus diarrhea, hospitalizations, medical attention due to rotavirus and severe diarrhea from all causes. The vaccines are not associated with increased numbers of serious adverse events, according to a new review.

Vaccination of infants with Rotarix or RotaTeq significantly reduces the rate of severe rotavirus diarrhoea, hospitalizations, medical attention due to rotavirus and severe diarrhoea from all causes. The vaccines are not associated with increased numbers of serious adverse events. These are the conclusions of a Cochrane Systematic Review published in the May 2010 issue of The Cochrane Library.

Rotavirus infection is the most common cause of severe diarrhoea in infants and young children, with the peak incidence of disease occurring between six and 24 months of age. Symptoms can range from mild illness, to hospitalization and death. Rotavirus infections cause over half a million deaths per year in children younger than five years, especially in low- and middle-income countries. The virus also results in higher diarrhoea-related death in children less than five years of age than any other single agent, particularly in low- and middle-income countries.

The researchers identified 34 trials that met their inclusion criteria, of which 26 evaluated Rotarix (GSK Biologicals, Belgium) and 8 evaluated RotaTeq (Merck & co., USA). Together, these trials included 175,944 participants. The study also searched for data on the use of Lanzhou Lamb Rotavirus (LLR) vaccine, which is approved for use only in China, but did not identify any trials that met their inclusion criteria. Rotarix and RotaTeq reduced all cases of rotavirus diarrhoea by 76% and 73% respectively at one year of age, and by 67% and 62% respectively at age two years. Severe rotavirus disease was reduced by 72% and 93% respectively at one year and 67% and 89% respectively at two years.

"Discovering just how effective both of these vaccines are at combating rotavirus disease will inform decision-making and support vaccine introduction," says Karla Soares-Weiser, who works at Enhance Reviews Ltd, London and leads a world-wide team of academic and medical researchers.

"New trials with head-to-head comparisons of both vaccines are needed, as well as trials comparing LLR vaccine with placebo, data for special groups of children, such as preterm infants and malnourished children, and careful monitoring of adverse events where vaccines are routinely used," says Soares-Weiser.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Soares-Weiser K, MacLehose H, Ben-Aharon I, Goldberg E, Pitan F, Cunliffe N. Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database of Systematic Reviews, 2010; Issue 5. Art. No.: CD008521 DOI: 10.1002/14651858.CD008521

Cite This Page:

Wiley-Blackwell. "Vaccination reduces burden of childhood rotavirus disease." ScienceDaily. ScienceDaily, 13 May 2010. <www.sciencedaily.com/releases/2010/05/100511192252.htm>.
Wiley-Blackwell. (2010, May 13). Vaccination reduces burden of childhood rotavirus disease. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/05/100511192252.htm
Wiley-Blackwell. "Vaccination reduces burden of childhood rotavirus disease." ScienceDaily. www.sciencedaily.com/releases/2010/05/100511192252.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins