Featured Research

from universities, journals, and other organizations

How do four caged xanthones inhibit cholangiocarcinoma cell growth?

Date:
May 12, 2010
Source:
World Journal of Gastroenterology
Summary:
Programmed cell death (apoptosis) is a key mechanism in the cell exploited by several currently used anticancer drugs to kill tumor cells. A study from Thailand found that the four caged xanthones from Garcinia hanburyi: isomorellin, isomorellinol, forbesione and gambogic acid, have strong growth inhibition effect in cholangiocarcinoma cells selectively. Growth suppression by these compounds was due to apoptosis.

Cholangiocarcinoma (CCA) is a malignant tumor, characterized by a poor prognosis and unresponsive to conventional chemotherapeutic agents. Therefore, searching for novel and effective therapeutic agents for CCA is necessary. In previous studies, several caged xanthones from G. hanburyi have been reported to be potent antiproliferatives as well as having anticancer and anti-tumor activities and they induce apoptosis in various cancer cell lines. However, the molecular target of these compounds remains unclear.

Related Articles


A research article to be published on May 14, 2010 in the World Journal of Gastroenterology addresses this question. Chariya Hahnvajanawong and her colleagues of the Khon Kaen University and Mahidol University found that the four caged xanthones can significantly inhibit the growth of CCA cell lines by modulating the expression of apoptotic-regulated genes and proteins.

This is the first report which shows that these compounds induce apoptosis by increasing the levels of proteins which promote apoptosis (Bax, apoptosis-inducing factor (AIF), activated caspase-9 and -3) while decreasing the levels of proteins which inhibit apoptosis (Bcl-2 and survivin).

In the view of the authors, the chemical structure diversity of the four compounds reflects the biological activities. At the molecular level, isomorellinol exhibited the highest potential, indicating that functional groups on the prenyl side chain may be important.

It is premature to conclude what the definite structure-activity relationship may be, but this preliminary insight provides a basis for further medicinal chemistry studies. Based on these results, the authors suggest that these four caged xanthones are compounds with great promise and may serve as a potential source and lead-structure for the development of a drug for the treatment of CCA.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hahnvajanawong C, Boonyanugomol W, Nasomyon T, Loilome W, Namwat N, Anantachoke N, Tassaneeyakul W, Sripa B, Namwat W, Reutrakul V. Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines. World Journal of Gastroenterology, 2010; 16 (18): 2235 DOI: 10.3748/wjg.v16.i18.2235

Cite This Page:

World Journal of Gastroenterology. "How do four caged xanthones inhibit cholangiocarcinoma cell growth?." ScienceDaily. ScienceDaily, 12 May 2010. <www.sciencedaily.com/releases/2010/05/100512112135.htm>.
World Journal of Gastroenterology. (2010, May 12). How do four caged xanthones inhibit cholangiocarcinoma cell growth?. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2010/05/100512112135.htm
World Journal of Gastroenterology. "How do four caged xanthones inhibit cholangiocarcinoma cell growth?." ScienceDaily. www.sciencedaily.com/releases/2010/05/100512112135.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins