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Higher HCC risk with increased insulin resistance in hepatitis C patients

Date:
May 12, 2010
Source:
World Journal of Gastroenterology
Summary:
Insulin resistance, a potential risk factor for a wide variety of cancers, has been reported to increase in chronic hepatitis C virus infection. A research group in Taiwan provided the first evidence that increased insulin resistance, regardless of type 2 diabetes mellitus, can potentially increase the risk of developing hepatocellular carcinoma in chronic hepatitis C patients in a cross-sectional, hospital-based setting.
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FULL STORY

Recent studies have demonstrated that type 2 diabetes mellitus (DM) is associated with high risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. Insulin resistance (IR), which correlates inversely with circulating adiponectin concentration, is a consistent finding in patients with type 2 DM. Chronic hepatitis C virus (HCV) infection has been reported to be associated with increased IR. Recent studies suggest that IR plays a crucial role in fibrosis progression, and has been demonstrated to have a negative impact on treatment responses to antiviral therapy in patients with chronic hepatitis C.

A research article to be published on May 14, 2010 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Hung from Kaohsiung Chang Gung Memorial Hospital prospectively investigated the IR assessed by the homeostasis model (HOMA-IR) and serum adiponectin level in two independent cohorts of consecutive newly diagnosed HCC patients and those with different clinical stages of chronic HCV infection. Among 165 HCC patients, type 2 DM was more prevalent in HCV subjects compared to hepatitis B virus (HBV) or non-HBV, non-HCV cases. HOMA-IR was higher in HCC patients with HCV than in those with HBV infection. In 188 patients with chronic hepatitis C, HCC subjects had higher blood sugar, insulin level and HOMA-IR than those with chronic hepatitis and advanced fibrosis.

Based on stepwise logistic regression analysis, HOMA-IR was one of the independent factors associated with HCC development. This result was similar even if the diabetic subjects were excluded for analysis. The research team concluded that increased IR, regardless of the presence of diabetes, is significantly associated with HCC development in patients with chronic HCV infection.

These findings may have important prognostic and therapeutic implications in the management of chronic HCV-infected patients. Since IR is a potentially modifiable factor, therapeutic intervention aimed at decreasing IR may be warranted in these patients.


Story Source:

The above post is reprinted from materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hung CH, Wang JH, Hu TH, Chen CH, Chang KC, Yen YH, Kuo YH, Tsai MC, Lu SN, Lee CM. Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. World Journal of Gastroenterology, 2010; 16 (18): 2265 DOI: 10.3748/wjg.v16.i18.2265

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World Journal of Gastroenterology. "Higher HCC risk with increased insulin resistance in hepatitis C patients." ScienceDaily. ScienceDaily, 12 May 2010. <www.sciencedaily.com/releases/2010/05/100512112141.htm>.
World Journal of Gastroenterology. (2010, May 12). Higher HCC risk with increased insulin resistance in hepatitis C patients. ScienceDaily. Retrieved August 3, 2015 from www.sciencedaily.com/releases/2010/05/100512112141.htm
World Journal of Gastroenterology. "Higher HCC risk with increased insulin resistance in hepatitis C patients." ScienceDaily. www.sciencedaily.com/releases/2010/05/100512112141.htm (accessed August 3, 2015).

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