Featured Research

from universities, journals, and other organizations

Adhesion and immunomodulatory properties of a probiotic strain B. lactis HN019

Date:
May 12, 2010
Source:
World Journal of Gastroenterology
Summary:
A research group from China elucidated the adherence and immunomodulatory properties of a world-wide consumed probiotic strain Bifidobacterium lactis HN019. The data from the studies revealed this probiotic strain has involved in maintaining intestinal homeostasis and it is a potential candidate for the new functional foods helpful in counteracting enteropathogen infections. This knowledge will contribute to offer, in the near future, new therapeutic means to counteract the inflammatory disorders observed in human inflammatory bowel disease.

Probiotics are a group of live microorganisms administered in adequate amounts which confer a beneficial health effect on the host. This bacterial community plays a pivotal role in human nutrition and health by promoting the supply of nutrients, preventing pathogen colonization and shaping and maintaining normal mucosal immunity. While the precise mechanistic basis of the beneficial effects of probiotics is obscure and will most likely vary depending on the strain and species used.

A research article to be published on May 14, 2010 in the World Journal of Gastroenterology focused their studies mainly on how Intestinal Epithelium Cells (IECs) respond to a widely used probiotic strain B. lactis HN019, in so doing to reveal the mechanism of immunomodulatory effect of B. lactis HN019. The research team is led by Professor Guo from Shanghai Jiao Tong University, school of medicine. Adhesion assays of B. lactis HN019 and S. typhimurium ATCC 14028 to INT-407 cells were carried out by detecting copies of species-specific genes with Real-time PCR. Ultrastructure research was further conducted by transmission electron microscopy. Interleukin-1β, Interleukin-8, Tumor necrosis factor-α gene expression were assessed while enzyme linked immunosorbent assay was used to detect IL-8 protein secretion.

The results showed that the attachment of S. typhimurium ATCC 14028 to INT407 intestinal epithelial cells was inhibited significantly by B. lactis HN019. It is also important to note that B. lactis HN019 could be internalized into the INT-407 cells. B. lactis HN019 attenuated both IL-8 mRNA level at baseline and S. typhimurium-induced pro-inflammatory responses. IL-8 secretion was reduced while IL-1β and TNF-α mRNA expression level was not changed at baseline after treated with B. lactis HN019.

As a probiotic strain, B. lactis HN019 could modulate immune system towards anti-inflammatory action and exclude enteropathogen adhesion, in so doing contributing to the homeostasis of the intestinal epithelium. This knowledge will contribute to offer, in the near future, new therapeutic means to counteract the inflammatory disorders observed in human inflammatory bowel disease.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Liu C, Zhang ZY, Dong K, Guo XK. Adhesion and immunomodulatory effects of Bifidobacterium lactis HN019 on intestinal epithelial cells INT-407. World Journal of Gastroenterology, 2010; 16 (18): 2283 DOI: 10.3748/wjg.v16.i18.2283

Cite This Page:

World Journal of Gastroenterology. "Adhesion and immunomodulatory properties of a probiotic strain B. lactis HN019." ScienceDaily. ScienceDaily, 12 May 2010. <www.sciencedaily.com/releases/2010/05/100512112143.htm>.
World Journal of Gastroenterology. (2010, May 12). Adhesion and immunomodulatory properties of a probiotic strain B. lactis HN019. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2010/05/100512112143.htm
World Journal of Gastroenterology. "Adhesion and immunomodulatory properties of a probiotic strain B. lactis HN019." ScienceDaily. www.sciencedaily.com/releases/2010/05/100512112143.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins