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Pressure testing tiny cell samples

Date:
May 25, 2010
Source:
American Physical Society
Summary:
A new pipette test offers a versatile way to study tissue mechanics.

A collaboration of French and Canadian researchers have found that sucking a portion of a spherical globule of cells into a tiny pipette provides information about the adhesion between cells and the elastic properties of the tissue. The method is a novel approach for the study of the structural properties of tissues, and should offer insights into processes such as embryonic development, tissue growth and cancer. A paper describing the research appears online in Physical Review Letters on May 24.

Conventional techniques for measuring the structural properties of tissues typically involved placing a sample between a pair of plates and observing how the tissue responds to compression. The new pipette technique complements the parallel plate method, as well as allowing researchers to obtain a wider range of measurements. In addition, the pipette approach could potentially allow for measurements to be performed on living tissue in its natural environment.

In a Viewpoint article in the current issue of APS Physics Gabor Forgacs and Ioan Kosztin of the University of Missouri note that interpretations of pipette-based cell measurements are somewhat unclear, in part because relatively few cells from a sample are sucked into the pipette. The technique is also limited to cells that bind together strongly. Nevertheless, pipette measurements offer a novel tool for studying cell development and diseases, as well as potentially aiding researchers involved in tissue engineering for growing artificial organs.


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The above story is based on materials provided by American Physical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Physical Society. "Pressure testing tiny cell samples." ScienceDaily. ScienceDaily, 25 May 2010. <www.sciencedaily.com/releases/2010/05/100525133211.htm>.
American Physical Society. (2010, May 25). Pressure testing tiny cell samples. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/05/100525133211.htm
American Physical Society. "Pressure testing tiny cell samples." ScienceDaily. www.sciencedaily.com/releases/2010/05/100525133211.htm (accessed July 31, 2014).

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