Featured Research

from universities, journals, and other organizations

Subtyping breast cancer by immunohistochemistry to investigate survival terms

Date:
May 25, 2010
Source:
Public Library of Science
Summary:
A new study evaluates immunohistochemistry-based subtype classification of breast tumors for the prediction of disease outcome.

A study by Paul Pharoah and colleagues published in this week's PLoS Medicine evaluates immunohistochemistry-based subtype classification of breast tumors for the prediction of disease outcome. Their analysis is based on more than 10,000 breast cancer cases with early disease, and examines the influence of a patient's tumour type on the prediction of future survival.

As has been shown previously the three subtypes of ER negative disease have a poorer outcome than the ER positive disease subtypes in the short term. However, this study has shown that in the long term, the ER negative disease subtypes have a better prognosis. This study has also conclusively demonstrated that the so-called triple negative tumours (ER-, PR- and HER2-) can be divided into two sub-types (basal and non-basal) with the basal subtype having a poorer prognosis.

The observed survival patterns were independent of any systemic adjuvant therapy, suggesting that tumour biology and molecular heterogeneity within breast cancer subtypes, rather than the choice of therapy, determined the survival trends. The authors recommend that this prognostic method should be incorporated into clinical practice.

A related Perspective by Stefan Ambs in the same issue examines the clinical significance of this large study and discusses the limitations of subtype classification for prognostication and targeted therapy in the management of breast cancer.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Blows FM, Driver KE, Schmidt MK, Broeks A, van Leeuwen FE, et al. Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies. PLoS Medicine, 2010; 7 (5): e1000279 DOI: 10.1371/journal.pmed.1000279

Cite This Page:

Public Library of Science. "Subtyping breast cancer by immunohistochemistry to investigate survival terms." ScienceDaily. ScienceDaily, 25 May 2010. <www.sciencedaily.com/releases/2010/05/100525171221.htm>.
Public Library of Science. (2010, May 25). Subtyping breast cancer by immunohistochemistry to investigate survival terms. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2010/05/100525171221.htm
Public Library of Science. "Subtyping breast cancer by immunohistochemistry to investigate survival terms." ScienceDaily. www.sciencedaily.com/releases/2010/05/100525171221.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins