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Little-known mouth fluid may lead to test for gum disease

Date:
May 28, 2010
Source:
American Chemical Society
Summary:
A little-known fluid produced in tiny amounts in the gums, those tough pink tissues that hold the teeth in place, has become a hot topic for scientists trying to develop an early, noninvasive test for gum disease, the No. 1 cause of tooth loss in adults. It's gingival crevicular fluid (GCF), produced at the rate of millionths of a quart per tooth.

The gums produce a little-known fluid that could provide the basis of an early, noninvasive test for gum disease.
Credit: iStockphoto

A little-known fluid produced in tiny amounts in the gums, those tough pink tissues that hold the teeth in place, has become a hot topic for scientists trying to develop an early, non-invasive test for gum disease, the No. 1 cause of tooth loss in adults. It's not saliva, a quart of which people produce each day, but gingival crevicular fluid (GCF), produced at the rate of millionths of a quart per tooth.

The study, the most comprehensive analysis of GCF to date, appears in ACS' monthly Journal of Proteome Research.

Eric Reynolds and colleagues note that GCF accumulates at sites of inflammation in the crevice between teeth and gums. Since dental workers can easily collect the fluid from patients, GCF has become a prime candidate for a simple inexpensive test to distinguish mild gum disease from the serious form that leads to tooth loss. But researchers have little information about the chemical composition of GCF.

The scientists collected GCF samples from 12 patients with a history of gum disease. Using high-tech instruments, they identified 66 proteins, 43 of which they found in the fluid for the first time. The fluid contained proteins from several sources, including bacteria and the breakdown products of gum tissue and bone, they note. They also identified antibacterial substances involved in fighting infection.

The findings advance efforts to develop an early test for gum disease, they suggest.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Luan H. Ngo, Paul D. Veith, Yu-Yen Chen, Dina Chen, Ivan B. Darby, Eric C. Reynolds. Mass Spectrometric Analyses of Peptides and Proteins in Human Gingival Crevicular Fluid. Journal of Proteome Research, 2010; 9 (4): 1683 DOI: 10.1021/pr900775s

Cite This Page:

American Chemical Society. "Little-known mouth fluid may lead to test for gum disease." ScienceDaily. ScienceDaily, 28 May 2010. <www.sciencedaily.com/releases/2010/05/100526124719.htm>.
American Chemical Society. (2010, May 28). Little-known mouth fluid may lead to test for gum disease. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/05/100526124719.htm
American Chemical Society. "Little-known mouth fluid may lead to test for gum disease." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526124719.htm (accessed August 1, 2014).

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