Featured Research

from universities, journals, and other organizations

Little-known mouth fluid may lead to test for gum disease

Date:
May 28, 2010
Source:
American Chemical Society
Summary:
A little-known fluid produced in tiny amounts in the gums, those tough pink tissues that hold the teeth in place, has become a hot topic for scientists trying to develop an early, noninvasive test for gum disease, the No. 1 cause of tooth loss in adults. It's gingival crevicular fluid (GCF), produced at the rate of millionths of a quart per tooth.

The gums produce a little-known fluid that could provide the basis of an early, noninvasive test for gum disease.
Credit: iStockphoto

A little-known fluid produced in tiny amounts in the gums, those tough pink tissues that hold the teeth in place, has become a hot topic for scientists trying to develop an early, non-invasive test for gum disease, the No. 1 cause of tooth loss in adults. It's not saliva, a quart of which people produce each day, but gingival crevicular fluid (GCF), produced at the rate of millionths of a quart per tooth.

Related Articles


The study, the most comprehensive analysis of GCF to date, appears in ACS' monthly Journal of Proteome Research.

Eric Reynolds and colleagues note that GCF accumulates at sites of inflammation in the crevice between teeth and gums. Since dental workers can easily collect the fluid from patients, GCF has become a prime candidate for a simple inexpensive test to distinguish mild gum disease from the serious form that leads to tooth loss. But researchers have little information about the chemical composition of GCF.

The scientists collected GCF samples from 12 patients with a history of gum disease. Using high-tech instruments, they identified 66 proteins, 43 of which they found in the fluid for the first time. The fluid contained proteins from several sources, including bacteria and the breakdown products of gum tissue and bone, they note. They also identified antibacterial substances involved in fighting infection.

The findings advance efforts to develop an early test for gum disease, they suggest.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Luan H. Ngo, Paul D. Veith, Yu-Yen Chen, Dina Chen, Ivan B. Darby, Eric C. Reynolds. Mass Spectrometric Analyses of Peptides and Proteins in Human Gingival Crevicular Fluid. Journal of Proteome Research, 2010; 9 (4): 1683 DOI: 10.1021/pr900775s

Cite This Page:

American Chemical Society. "Little-known mouth fluid may lead to test for gum disease." ScienceDaily. ScienceDaily, 28 May 2010. <www.sciencedaily.com/releases/2010/05/100526124719.htm>.
American Chemical Society. (2010, May 28). Little-known mouth fluid may lead to test for gum disease. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2010/05/100526124719.htm
American Chemical Society. "Little-known mouth fluid may lead to test for gum disease." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526124719.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins