Featured Research

from universities, journals, and other organizations

Radioactive optical imaging and 'quantum dot' nano-imaging at the forefront of molecular medicine

Date:
June 8, 2010
Source:
Society of Nuclear Medicine
Summary:
Researchers have presented the results of a multidisciplinary study involving the capture of radiation luminescence and radioactive-excited nanoparticles to help detect subtle signs of disease. Currently, nuclear medicine agents and imaging technology image the behavior of particles at the cellular, molecular and atomic levels, but radioactive materials also emit barely visible light that can be detected with highly sensitive optical imaging technology. This discovery could lead to new, state-of-the-art imaging techniques.

During the Society of Nuclear Medicine's 57th Annual Meeting, investigators presented the results of a multidisciplinary study involving the capture of radiation luminescence and radioactive-excited nanoparticles to help detect subtle signs of disease. Currently, nuclear medicine agents and imaging technology image the behavior of particles at the cellular, molecular and atomic levels, but radioactive materials also emit barely visible light that can be detected with highly sensitive optical imaging technology. This discovery could lead to new, state-of-the-art imaging techniques.

Related Articles


"The need for this study became evident with the rise of new molecular imaging research and multimodality imaging instruments and probes, which could provide better and earlier diagnosis for a variety of diseases," said Zhen Cheng, Ph.D., co-author of the study and assistant professor of radiology at Stanford University. "The research presented here bridges nuclear imaging and optical imaging. It represents a new avenue for molecular imaging research, and is expected to have many applications for medical and bionanotechnology research as well as clinical imaging."

Study researchers focused on a low-energy window of light from the visible and near-infrared band of the electromagnetic spectrum. This is not visible to the human eye, but can be detected with very precise optical cameras picking up light energy from the charged particles of radioactive sources. Researchers tested commonly employed molecular imaging agents used to detect a range of biological processes within the body. Imaging agents utilized in the study include fluorine-based 18F-FDG and Na18F, sodium iodide-based Na131I, yttrium-based 90Y-Cl3, as well as a 90Y labeled peptide that specifically target tumors.

Findings indicate that radioactive molecular probes and nano-imaging techniques using radiation luminescence and widely studied fluorescent nanoparticles known as "quantum dots" could potentially be used for non-invasive functional imaging with optical imaging systems. Not only could this have a significant impact on the early detection and diagnosis of disease, but these and resulting techniques could also be applied to future applications in image-guided therapy.

The two papers associated with the study were also selected as winners of SNM's Molecular Imaging Center of Excellence Young Investigator Award, presented during SNM's Annual Meeting in Salt Lake City.

Scientific Paper 1: H. Liu, G. Ren, Z. Miao, X. Zhang, S.S. Gambhir, Z. Cheng, Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University, Stanford, Calif.; X. Tang, Department of Physics, University of Notre Dame, Notre Dame, Ind.; P. Han, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Tianjin, China; "Noninvasive molecular imaging of radioactive tracers using optical imaging techniques"

Scientific Paper 2: H. Liu, G. Ren, Z. Miao, X. Zhang, S.S. Gambhir, Z. Cheng, Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University, Stanford, Calif.; B. Xing, Division of Chemistry and Biological chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore; P. Han, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Tianjin, China; "In vivo multiplexed optical imaging with radiation luminescence excited quantum dots"


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "Radioactive optical imaging and 'quantum dot' nano-imaging at the forefront of molecular medicine." ScienceDaily. ScienceDaily, 8 June 2010. <www.sciencedaily.com/releases/2010/06/100607142009.htm>.
Society of Nuclear Medicine. (2010, June 8). Radioactive optical imaging and 'quantum dot' nano-imaging at the forefront of molecular medicine. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/06/100607142009.htm
Society of Nuclear Medicine. "Radioactive optical imaging and 'quantum dot' nano-imaging at the forefront of molecular medicine." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607142009.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins