Featured Research

from universities, journals, and other organizations

Metabolic syndrome in living kidney donors worsens function of remaining kidney, study finds

Date:
June 21, 2010
Source:
The Endocrine Society
Summary:
People who donate one of their kidneys experience faster deterioration of their other kidney if they have the metabolic syndrome at the time of donation, a new study finds.

People who donate one of their kidneys experience faster deterioration of their other kidney if they have the metabolic syndrome at the time of donation, a new study finds.

The results are being presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

Each year more than 6,000 adults in the United States are living kidney donors. Over time, these donors typically have some decline in function of their remaining kidney, depending on their age and other factors. However, the new study found that kidney function decreases more than twice as fast in donors who have a cluster of cardiovascular risk factors known as the metabolic syndrome.

"The metabolic syndrome before kidney donation can negatively affect a donor's kidney function outcome," said the study's lead author, Daniel Cuevas-Ramos, MD, a clinical researcher at Mexico's Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. "We recommend that living kidney donors correct any metabolic abnormalities before donation."

Diagnosis of the metabolic syndrome depends on the presence of at least three of the following: a large waistline, low HDL ("good") cholesterol, high triglycerides (levels of fat in the blood), high blood pressure and high blood glucose (blood sugar) at a level considered prediabetes or above. The metabolic syndrome, which affects one in five people in the United States, increases the chance of developing Type 2 diabetes, heart disease and stroke.

Cuevas-Ramos and his colleagues studied 140 adults who donated a kidney. Of those, 28 donors had the metabolic syndrome before donation and 112 did not. Using long-term follow-up data, the investigators determined each donor's kidney function after donation, measured by the glomerular filtration rate, or GFR, on a blood test. In general, a GFR below 70 milliliters per minute indicates below-normal kidney function.

The average time it took for donors' GFR to drop below 70 was less than six years in those who had the metabolic syndrome before donation versus approximately 13 years in donors without the syndrome.

"This study does not suggest that the metabolic syndrome is a contraindication for kidney donation but rather another potential risk factor for decline in renal function," Cuevas-Ramos said.

Medical reasons for rejecting a kidney donor, called contraindications, vary among U.S. transplant centers. However, diabetes, obesity, and high blood pressure are usually contraindications to donating a kidney.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "Metabolic syndrome in living kidney donors worsens function of remaining kidney, study finds." ScienceDaily. ScienceDaily, 21 June 2010. <www.sciencedaily.com/releases/2010/06/100621091207.htm>.
The Endocrine Society. (2010, June 21). Metabolic syndrome in living kidney donors worsens function of remaining kidney, study finds. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2010/06/100621091207.htm
The Endocrine Society. "Metabolic syndrome in living kidney donors worsens function of remaining kidney, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/06/100621091207.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins