Featured Research

from universities, journals, and other organizations

Insight into cells could lead to new approach to medicines

Date:
June 22, 2010
Source:
University of Edinburgh
Summary:
A surprising discovery about the complex make-up of our cells could lead to the development of new types of medicines, a study suggests.

A surprising discovery about the complex make-up of our cells could lead to the development of new types of medicines, a study suggests.

Scientists studying interactions between cell proteins -- which enable the cells in our bodies to function -- have shown that proteins communicate not by a series of simple one-to-one communications, but by a complex network of chemical messages.

The findings suggest that medicines would be more effective if they were designed differently. Drugs could have a greater effect on cell function by targeting groups of proteins working together, rather than individual proteins.

Results were obtained by studying yeast, which has many corresponding proteins in human cells. Researchers, including scientists from the University of Edinburgh, used advanced technology to identify hundreds of different proteins, and then used statistical analysis to identify the more important links between them, mapping almost 2000 connections in all.

Scientists expected to find simple links between individual proteins but were surprised to find that proteins were inter-connected in a complex web.

Dr Victor Neduva, of the University of Edinburgh, who took part in the study, said: "Our studies have revealed an intricate network of proteins within cells that is much more complex than we previously thought. This suggests that drugs should be more complex to treat illnesses effectively.

Professor Mike Tyers, who led the study, said: "Medicines could work better if they targeted networks of proteins rather than sole proteins associated with particular illnesses."

The research, published in Science, carried out in collaboration with Mount Sinai Hospital, Ontario and the Universities of Michigan and Toronto, was supported by the Royal Society and the Scottish Universities Life Sciences Alliance.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Breitkreutz, H. Choi, J. R. Sharom, L. Boucher, V. Neduva, B. Larsen, Z. Y. Lin, B. J. Breitkreutz, C. Stark, G. Liu, J. Ahn, D. Dewar-Darch, T. Reguly, X. Tang, R. Almeida, Z. S. Qin, T. Pawson, A. C. Gingras, A. I. Nesvizhskii, M. Tyers. A Global Protein Kinase and Phosphatase Interaction Network in Yeast. Science, 2010; 328 (5981): 1043 DOI: 10.1126/science.1176495

Cite This Page:

University of Edinburgh. "Insight into cells could lead to new approach to medicines." ScienceDaily. ScienceDaily, 22 June 2010. <www.sciencedaily.com/releases/2010/06/100621215952.htm>.
University of Edinburgh. (2010, June 22). Insight into cells could lead to new approach to medicines. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/06/100621215952.htm
University of Edinburgh. "Insight into cells could lead to new approach to medicines." ScienceDaily. www.sciencedaily.com/releases/2010/06/100621215952.htm (accessed September 30, 2014).

Share This



More Plants & Animals News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

California University Designs Sustainable Winery

California University Designs Sustainable Winery

Reuters - US Online Video (Sep. 27, 2014) Amid California's worst drought in decades, scientists at UC Davis design a sustainable winery that includes a water recycling system. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
Argentina Worries Over Decline of Soybean Prices

Argentina Worries Over Decline of Soybean Prices

AFP (Sep. 27, 2014) The drop in price of soy on the international market is a cause for concern in Argentina, as soybean exports are a major source of income for Latin America's third largest economy. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Mama Bear, Cubs Hang out in California Backyard

Mama Bear, Cubs Hang out in California Backyard

Reuters - US Online Video (Sep. 27, 2014) A mama bear and her two cubs climb trees, wrestle and take naps in the backyard of a Monrovia, California home. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
'Crazy' Climate Forces Colombian Farmers to Adapt

'Crazy' Climate Forces Colombian Farmers to Adapt

AFP (Sep. 26, 2014) Once upon a time, farming was a blissfully low-tech business on Colombia's northern plains. Duration: 02:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins