June 22, 2010 A surprising discovery about the complex make-up of our cells could lead to the development of new types of medicines, a study suggests.
Scientists studying interactions between cell proteins -- which enable the cells in our bodies to function -- have shown that proteins communicate not by a series of simple one-to-one communications, but by a complex network of chemical messages.
The findings suggest that medicines would be more effective if they were designed differently. Drugs could have a greater effect on cell function by targeting groups of proteins working together, rather than individual proteins.
Results were obtained by studying yeast, which has many corresponding proteins in human cells. Researchers, including scientists from the University of Edinburgh, used advanced technology to identify hundreds of different proteins, and then used statistical analysis to identify the more important links between them, mapping almost 2000 connections in all.
Scientists expected to find simple links between individual proteins but were surprised to find that proteins were inter-connected in a complex web.
Dr Victor Neduva, of the University of Edinburgh, who took part in the study, said: "Our studies have revealed an intricate network of proteins within cells that is much more complex than we previously thought. This suggests that drugs should be more complex to treat illnesses effectively.
Professor Mike Tyers, who led the study, said: "Medicines could work better if they targeted networks of proteins rather than sole proteins associated with particular illnesses."
The research, published in Science, carried out in collaboration with Mount Sinai Hospital, Ontario and the Universities of Michigan and Toronto, was supported by the Royal Society and the Scottish Universities Life Sciences Alliance.
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- A. Breitkreutz, H. Choi, J. R. Sharom, L. Boucher, V. Neduva, B. Larsen, Z. Y. Lin, B. J. Breitkreutz, C. Stark, G. Liu, J. Ahn, D. Dewar-Darch, T. Reguly, X. Tang, R. Almeida, Z. S. Qin, T. Pawson, A. C. Gingras, A. I. Nesvizhskii, M. Tyers. A Global Protein Kinase and Phosphatase Interaction Network in Yeast. Science, 2010; 328 (5981): 1043 DOI: 10.1126/science.1176495
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