Featured Research

from universities, journals, and other organizations

Detecting eye injury

Date:
June 26, 2010
Source:
American Journal of Pathology
Summary:
Scientists have developed a noninvasive imaging technique to detect early stages of eye disease.

Dr. Ali Hafezi-Moghadam and colleagues at the Harvard Medical School, Boston, MA have developed a noninvasive imaging technique to detect early stages of eye disease. These results are presented in the July 2010 issue of The American Journal of Pathology.

Related Articles


Uveitis, inflammation of the middle layer of the eye, is the most common form of eye disease, causing up to 10% of visual loss in the United States. Early detection of uveitis could lead to earlier treatment and prevent irreversible tissue damage and loss of sight.

In uveitis, white blood cells accumulate in affected regions of the eye. Therefore, Xie et al used fluorescently-labeled molecules (microspheres) that bind to P-selectin, an adhesion molecule that binds to white blood cells, to identify areas of the eye with uveitis. These microspheres mimicked white blood cell accumulation in an animal model of uveitis, and binding was decreased when these animals were treated with topical anti-inflammatory drugs, allowing for quantification of the immune response. As microvessel accumulation precedes clinical signs of disease, this noninvasive imaging technique may provide a model system for studying the early stages of anterior uveitis.

Dr. Hafezi-Moghadam's group concludes that "our imaging approach detects the earliest signs of disease, even prior to the occurrence of clinical symptoms, such as leakage, pain, or vision deterioration. Upon subclinical detection of molecular changes, effective treatments could be instituted to halt inflammation, before irreversible structural damage occurs. Besides being a powerful research tool, this versatile imaging approach has a high chance of being translated to the clinical realm and impacting the way medicine is practiced."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xie F, Sun D, Schering A, Nakao S, Zandi S, Liu P, Hafezi-Moghadam A. Novel Molecular Imaging Approach for Subclinical Detection of Iritis and Evaluation of Therapeutic Success. Am J Pathol, 2010, 177: 39-48

Cite This Page:

American Journal of Pathology. "Detecting eye injury." ScienceDaily. ScienceDaily, 26 June 2010. <www.sciencedaily.com/releases/2010/06/100625101100.htm>.
American Journal of Pathology. (2010, June 26). Detecting eye injury. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2010/06/100625101100.htm
American Journal of Pathology. "Detecting eye injury." ScienceDaily. www.sciencedaily.com/releases/2010/06/100625101100.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins